List of miRNAs based therapeutics in their clinical trials

Therapeutics based on miRNAs and names of companiesTherapeutic agentThe system used for deliveryDisease targetedStage of clinical trial Gov identifier of clinical trial
Miravirsen (Santaris Pharma)AntimiR-122Antisense inhibitor with LNA modificationChronic hepatitis CPhase I is completedNCT00688012, NCT00979927, NCT01646489
RG-101 (Regulus-therapeutics)AntimiR-122AntimiR conjugated with GalNacChronic hepatitis CPhase II is completedEudraCT numbers 2015-001535-21, 2015-004702-42
RG-125/AZD4076 (Regulus-therapeutics)AntimiR-103/107AntimiR conjugated with GalNacPatient with type 2 diabetesPhase I is completedNCT02612662, NCT02826525
MRG-106 (miRagen-therapeutics)AntimiR-155Antisense inhibitor with LNA modificationMycosis fungoides and cutaneous T cell lymphomaPhase I is completedNCT02580552
MRG-201 (miRagen-therapeutics)miR-29 mimicmiRNA duplex with cholesterol conjugationSclerodermaPhase II is completedNCT02603224
MesomiR-1 (EnGeneIC)miR-16 mimicDelivery vehicle of EnGeneICMesothelioma and NSCLCPhase I is completedNCT02369198
MRX34 (miRNA therapeutics)miR-34 mimicLipid nanoparticlesMultiple-solid tumorsPhase I is terminatedNCT01829971

EudraCT numbered trials are registered at EU Clinical Trials Register (clinicaltrialsregister.eu). Gov: government; LNA: locked nucleic acid; NSCLC: non-small cell lung cancer; GalNac: N-acetyl-galactosamine