Table Info

Table 3.

Alterations in Notch pathway according to BC subtype [165]

Subtype	BC subtype
Subtype	HER2⁺	Basal-like	Luminal A	Luminal B
Notch activation (mRNA, protein)	- High Notch2 expression - Notch4 expression positively correlates with ER positivity - Notch1 expression inversely correlates with HER2 expression - Absence of ER expression correlates with higher Notch3 expression - Notch1 expression inversely correlates with ER and PR expression	- High Notch2 expression - TNBCs highly express Notch1–3 - Absence of ER expression correlates with higher Notch3 expression - Notch1 expression in 100% of TNBCs assessed - Notch4 expression in 73% of TNBCs assessed - Low Notch3 expression in TNBC compared to luminal A tumors - Notch1 enriched in the basal subtype	- High Notch2 expression - Notch4 expression positively correlates with ER positivity - Notch1 expression inversely correlates with HER2 expression - High Notch3 expression compared to TNBC - Notch1 expression inversely correlates with ER and PR expression	- High Notch2 expression - Notch4 expression positively correlates with ER positivity - Notch1 expression inversely correlates with HER2 expression - Notch1 expression inversely correlates with ER and PR expression

Note. Adapted from “Moving breast cancer therapy up a notch,” by Mollen EWJ, Ient J, Tjan-Heijnen VCG, Boersma LJ, Miele L, Smidt ML, et al. Front Oncol. 2018;8:518 (https://www.frontiersin.org/articles/10.3389/fonc.2018.00518/full). CC BY.

Declarations

Acknowledgments

The authors acknowledge Joana Cavaco Silva for assisting in manuscript revision.

Author contributions

ISP: contributed to the manuscript design and literature analysis, wrote part of the introduction and the NFκB pathway as well as global revision to the article.

CA: contributed to the initial design of the article, wrote Notch pathway and a substantial contribution and regulators of cell cycle apoptosis, as well as to global manuscript revision.

IG: contributed to the manuscript design and literature analysis, wrote part of the introduction and created some figures.

SC: wrote the RANK-RANKL pathway chapter, and full manuscript revision.

TRP: made the revision of TKRs and alternative pathways, made Table 2 and Figures 3 and 4; also contributed to global manuscript revision.

RTS: specially contributed for the initial design of the article, contributed to the conclusion and review the final manuscript.

LC: contributed to conceptualization, design, direction and overall supervision of the manuscript.

All the authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

IG is supported by the FCT PhD grant SFRH/BD/139178/2018. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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