Summary of broad treatment options with general indications and limitations

InterventionIndicationLimitations
Surgical resectionSingle lesion resection and symptom reliefMultiple disseminated lesions
Whole-brain radiotherapyHigh metastatic tumor load (> 10 metastases)Off-target radiation with neurological decline
Stereotactic radiosurgeryLesion diameters < 3 cmHigh metastatic tumor load (> 10 metastases)
Systemic therapyTherapeutic targets presentLack of therapeutic targets