Table Info

Table 1.

An overview of proteins that have been shown to modulate Bax-induced cell death in yeast

Function	Activation: overexpression stimulates Bax effects and/or deletion inhibits Bax effects		Inhibition: overexpression inhibits Bax effects and/or deletion stimulates Bax effects
Function	Mammalian proteins	Yeast proteins	Mammalian proteins	Yeast proteins	Plant and viral proteins
Bcl-2 family and related	tBid [171, 172] Puma [173] Noxa, Bik [174]		Bcl-2, Bcl-xL [22, 39, 44, 46, 175] Bfl-1/A1 [176]	see below for Ybh3	M11 [177] DPV022 [178]
Bax-inhibitor			BI-1 [50]	BI-1/Bxi1/Ybh3 [59] (not tested with Bax in [89, 90])	BI-1 [59, 61, 179, 180]
Traffic	Tom22 [135, 137]	Tom22 [135, 139] TOM complex [136] Mdm34 [148]	Vps34 [54] Vamp3 [181]	Sec22 [182]	AtVAMP [63]
Autophagy and protein quality control		Uth1 [73, 183] Yme1 [184] Naa20 [185]		Atg5, Atg7 [73]	Sentrin [186]
Protein aggregates			PrP [187,188] α-synuclein [189]
Protein- kinases	AKT [128] PKCα [190]		AKT [128]	Sch9 [191]
Stress responses		Hsp60 [192] Hog1 [193]	Trx1 [194] Fth1 [195]	Tsa1 [194] Rgi1 [195]	tQM [196] LePHGPx [64] AtEBP [62, 65] BI-GST [60, 197] sAPX [198]
Energetic metabolism		Qcr7, Cyc3, Cox4, Cox7, Atp4, Pet9 [161, 199] Data not confirmed in [155]	COX6A1 [200]	OYE2 [69, 201] Por1 [199]	GAPDH [202]
Lipid metabolism			SMS1 [203]	Hfd1 [184] Fah1 [204]	fah1, fah2 [204] BcLCB(2) [205]
Others			hRPL9 [206] Septin7 [70] Tsc22 [55]	Cdc10 [70]	Omp2b [67]

Declarations

Acknowledgments

The work done in the lab of the author has been supported by the CNRS, the Université de Bordeaux, and the Ligue Régionale contre le Cancer. The author thanks all his present and former students and colleagues for these studies, namely Nadine Camougrand, Muriel Priault, Hubert Arokium, Ingrid Bhatia-Kiššová, Thibaud Renault, Dario Trindade, Lilit Simonyan and Akandé Rouchidane Eyitayo.

Author contributions

The author contributed solely to the work.

Conflicts of interest

The author declares no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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