Therapeutic targets and inhibitors

Target/Inhibitor Examples of preclinical sensitivity References
NHE1
  Amiloride Mammary, prostate, gastric, hepatoma [104]
  Ethylisopropylamiloride (EIPA) Bladder, breast cancer [109]
  Dimethylamiloride (DMA) Bladder, breast cancer [109]
  Hexamethyleneamiloride (HMA) Leukemia [110]
  Cariporide Leukemia, cholangiocarcinoma [12, 96103]
  Phx-3 Gastric cancer [111, 12]
MCT1/MCT4
  α-cyano-4-hydroxycinnamate Lung cancer [116]
  AZD 3965 Small cell lung cancer [131]
  AR-C155858 Rat transformed fibroblasts [121]
V-ATPases
  Balifomycin C Pancreatic cancer, colon cancer [157, 159]
  Concanamycin A Submandibular cancer [162]
  Esomerprazole Breast cancer, esophageal cancer [171, 172]
  Omeprazole Melanoma [168, 169]
  Lansoprazole Pancreatic cancer, breast cancer [166, 170]
CAIX
  Indisulam Lung cancer [208]
  VII/20 Monoclonal antibody Colon cancer [198]