Table Info

Table 1.

The summary of the roles of the major Ca²⁺ channel/pump/exchanger and Ca²⁺-handling proteins in regulation of cell cycle in lung cancer cells

Ca²⁺-channel/pump/exchangerand Ca²⁺-handling proteins	Cell line	Expression	Described roles
Orai3	NCI-H23 and NCI-H460	↑	Decreased SOCE, abolished cell proliferation and triggered cell cycle arrest at G0/G1 phase [42]
Orai1/CRACM1	A549	Not determined	Orai1/CRACM1 overexpression attenuated EGF-mediated store-operated (Ca²⁺)_e influx, and triggers G0/G1 cell cycle arrest [44]
STIM1	A549 SK-MES-1	↑	STIM1 silencing inhibited colony formation, and induced cell cycle arrest at G2/M and S phases [50]
CaMKII	NCI-H69, NCI-H128, NCI-H146 and NCI-H345	Not determined	KN-62-induced inhibition of CaMKII activity triggered reduced DNA synthesis and cell cycle arrest at S phase [52]
CaNAα	SBC-3	↑	Promoted G1/S phase transition [35]

↑

: increased

Declarations

Author contributions

The author contributed solely to the work.

Conflicts of interest

The author declares that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

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Consent to publication

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Availability of data and materials

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Funding

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Copyright

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