Multivariable analyses for OS

Clinical parameter Univariate cox regression Multivariate cox regression
HR (95% CI) P-value Exponentiation of the B coefficient (EXP B, 95% CI) P-value
Gender (male vs. female ) 0.72 (0.30–1.64) 0.4115
PS-ECOG (≥ 2 vs. < 2 ) 2,43 (1.19–10.56) 0.0226 0.37 (0.12–1.14) 0.0840
Age (≥ 70 vs. < 70 ) 1.44 (0.70–2.98) 0.3195
Histotype (squamous vs. non-squamous ) 1.08 (0.53–2.21) 0.8328
Smoke (yes vs. no ) 0.38 (0.17–3.95) 0.8074
BM (no vs. yes ) 3.28 (1.73–8.28) 0.0009 0.19 (0.05–0.78) 0.0222
Pulmonary metastases (no vs. yes ) 1.08 (0.36–3.23) 0.8845
Liver metastases (no vs. yes ) 0.45 (0.11–1.20) 0.0984
Cerebral metastases (no vs. yes ) 0.78 (0.20–2.85) 0.6751
Adrenal metastases (no vs. yes ) 0.66 (0.22–1.62) 0.3124
Lymph nodes metastases (no vs. yes ) 1.29 (0.53–3.33) 0.5502
Pleural metastases (no vs. yes ) 0.58 (0.24–1.21) 0.1368
Maximum lesion diameter (cut-off = 6.3 cm) 0.80 (0.35–1.86) 0.6097
Sum of the 5 major lesions diameters (cut-off = 14.3 cm) 1.35 (0.46–4.31) 0.5438
Intrathoracic vs. extrathoracic disease 0.40 (0.17–0.82) 0.0136 0.12 (0.03–0.52) 0.0212
Measurable vs. not-measurable disease 0.09 (0.08–0.44) < 0.0001 0.14 (0.02–0.74 0.0216
Number of metastatic sites (≥ 4 vs. < 4 ) 2.56 (1.33–8.63) 0.0106 0.65 (0.26–0.87) 0.0372