Table Info

Table 2.

Multivariable analyses for OS

Clinical parameter	Univariate cox regression		Multivariate cox regression
Clinical parameter	HR (95% CI)	P-value	Exponentiation of the B coefficient (EXP B, 95% CI)	P-value
Gender (male vs. female)	0.72 (0.30–1.64)	0.4115
PS-ECOG (≥ 2 vs. < 2)	2,43 (1.19–10.56)	0.0226	0.37 (0.12–1.14)	0.0840
Age (≥ 70 vs. < 70)	1.44 (0.70–2.98)	0.3195
Histotype (squamous vs. non-squamous)	1.08 (0.53–2.21)	0.8328
Smoke (yes vs. no)	0.38 (0.17–3.95)	0.8074
BM (no vs. yes)	3.28 (1.73–8.28)	0.0009	0.19 (0.05–0.78)	0.0222
Pulmonary metastases (no vs. yes)	1.08 (0.36–3.23)	0.8845
Liver metastases (no vs. yes)	0.45 (0.11–1.20)	0.0984
Cerebral metastases (no vs. yes)	0.78 (0.20–2.85)	0.6751
Adrenal metastases (no vs. yes)	0.66 (0.22–1.62)	0.3124
Lymph nodes metastases (no vs. yes)	1.29 (0.53–3.33)	0.5502
Pleural metastases (no vs. yes)	0.58 (0.24–1.21)	0.1368
Maximum lesion diameter (cut-off = 6.3 cm)	0.80 (0.35–1.86)	0.6097
Sum of the 5 major lesions diameters (cut-off = 14.3 cm)	1.35 (0.46–4.31)	0.5438
Intrathoracic vs. extrathoracic disease	0.40 (0.17–0.82)	0.0136	0.12 (0.03–0.52)	0.0212
Measurable vs. not-measurable disease	0.09 (0.08–0.44)	< 0.0001	0.14 (0.02–0.74	0.0216
Number of metastatic sites (≥ 4 vs. < 4)	2.56 (1.33–8.63)	0.0106	0.65 (0.26–0.87)	0.0372

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100243_sup_1.pdf.

Declarations

Author contributions

EL, SR, RB and ALC contributed conception and design of the study; AL, GM, VC, IF, LZ and SG organized the data; EL, SR, LC and MR performed the statistical analysis; EL, VC and AL wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

All authors declare that there are no conflicts of interest.

Ethical approval

The study was approved by the local Ethics Committee (ID of the study 2019-146). All procedures were performed by the ethics standards of our institutional research committee and with those of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Consent to participate

Written informed consent was obtained from all subjects before the study.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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