Parametric recalibration table: the table describes the possible mechanisms to restore CRD under different parametric conditions. Here Doxo 1, Doxo 2, Doxo 3 denotes the categories when the baseline parameter set is increased by 25%, 50%, 75% respectively

CategoryParametric variationPossible mechanism of restoration
Doxo 1Single paramer variation1. Decrease calcium influx rate through TRPC1 channel (γ)
2. Increase SOCE timescale (τs)
3. Decrease net calcium influx rate through plasma membrane (α)
4. Decrease extracellular calcium concentration (ces)
Doxo 2Single parameter variation1. Decrease TRPC1 calcium influx rate (γ)
2. Decrease extracellular calcium concentration (ces)
Doxo 3Double parameter variation1. Decrease SOCE flux rate (β) by 20% & decrease TRPC1 calcium influx rate (γ)
2. Decrease SOCE flux rate (β) by 20% & increase SOCE timescale (τs)
3. Decrease SOCE flux rate (β) by 20% & decrease SERCA1 channel’s half-saturation constant (q2)
4. Decrease SOCE flux rate (β) by 20% & decrease extracellular calcium concentration (ces)