Exploration of Targeted Anti-tumor Therapy

Table 8. General characteristics of studies on the association of NLR with conventional tumor markers of tCa

Reference	Sample size	Study design	Year of publication	Country	Histo pathology	Cut off value of NLR	Seminomatous tCa	Outcome
Arda et al. [26]	182	Retrospective cohort	2020	Turkey	TGCT	1.78	46.60%	B-HCG level was significantly higher in the patients with higher NLR.
Horsanali et al. [36]	128	Retrospective cohort	2017	Turkey	TGCT	3.72	44.80%	Levels of AFP, B-HCG, and LDH were significantly related to NLR level.
Olcucu et al. [44]	99	Retrospective cohort	2020	Turkey	TGCT	3.21	45.45%	NLR was significantly related to LDH level.
Bauzá Quetglas et al. [46]	80	Retrospective cohort	2020	Spain	tCa	2.25	62.50%	No correlation was observed between NLR and conventional tumor markers (AFP and B-HCG).

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tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio

Declarations

Author contributions

SS: Conceptualization. SB: Investigation, Writing—original draft. SK: Conceptualization, Writing—review & editing. AS: Investigation. AC: Investigation. DK: Writing—original draft. MK: Writing—review & editing. AG: Writing—review & editing. BLW: Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Datasets are available on request.

Funding

Not applicable.

Copyright

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