Exploration of Targeted Anti-tumor Therapy

Table 2. Database search engines and algorithms in database search engines used for identification of MHC binding peptides (pMHC) and post-translational modification (PTM) of identified peptides

Search engines	DB search	De novo peptide sequencing	PTM search^*
Proteome Discoverer	SEQUEST	INFERY™	ProsightPD
Maxquant	Andromeda	MaxNovo	Andromeda
PEAKS	PEAKS	PEAKS BD	GlycanFinder
MSFragger	MSFragger	n/a	MSFragger-glyco
MetaMorpheus	MetaMorpheus	n/a	G-PTM-D
PepNoVo+	n/a	PepNOVO+	n/a
SMSnet	SMSnet	SMSnet	SMSnet

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^* Database search for PTM can be phosphorylation, glycosylation, or other type of PTM

Declarations

Author contributions

SP: Conceptualization, Writing—review & editing. NK: Conceptualization, Visualization. PS: Conceptualization, Writing—review & editing. SR: Conceptualization, Writing—review & editing. YM: Conceptualization, Writing—review & editing. KP: Writing—review & editing. ST: Conceptualization, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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