Table Info

Table 1.

Classification of cancer antigens

Type of antigens	Antigen characteristics	Example of human tumor antigens
Cancer-germline	Expressed by tumor cells and adult reproductive tissues	MAGE, BAGE, NY-ESO-1
Differentiation	Expressed by tumors cells and a limited range of normal tissues	Tyrosinase, Melan-A/MART-1, Gp100, CEA
Overexpressed	Highly expressed in tumor cells and few in some normal tissues	EGFR, HER2, MUC1
Mutant neoantigens	Mutant antigens, expressed only by tumor cells as a result of mutation, patient-specific	p53, Ras, BCR-ABL, ACTN4
TEIPP neoantigens	Non-mutated antigens expressed by tumor cells with APM defects	ppCT, LRPAP1
Viral antigens	Expressed only by tumor cells as a result of viral infection	HPV E6–E7, EBV, HBV, HTVL

EGFR: epidermal growth factor receptor; HER2: human EGFR 2; ppCT: preprocalcitonin; HPV: human papillomavirus; EBV: Epstein-Barr virus; HBV: hepatitis B virus; HTVL: human T cell leukemia virus; APM: antigen presentation machinery; BAGE: B melanoma antigen; NY-ESO-1: New York esophageal squamous cell carcinoma 1; Gp100: glycoprotein 100; CEA: carcinoembryonic antigen; MUC1: mucin 1; p53: tumor protein 53; BCR-ABL: breakpoint cluster region and abelson oncogene; LRPAP1: LDL-receptor-related protein-associated protein 1; ACTN4: actinin 4

Declarations

Acknowledgments

The authors thank Sarah MacKenzie for editorial help.

Author contributions

MOA, SC and FMC: Conceptualization. MOA and SC: Creation of tables and figures. All authors contributed to the manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by grants from the French Institut National du Cancer (INCa; Grant number PRTK-2020-070); Agence Nationale de la Recherche (ANR-PRCE-2021, ANR-21-CE17-0049-01) and Fondation de France (2021; Grant number 00119144/WB-2021-34171). SC is supported by grants from Association pour la Recherche sur le Cancer (ARC; Grant number SIGN’IT20181007792). MOA is a recipient of a fellowship from Fondation de France (2021; Grant number 00119144/WB-2021-34171). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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