Exploration of Targeted Anti-tumor Therapy

Table 2. Patent survey of different nano-formulations of RSV

Patent number	Inventor name	Invention	Details	Reference
WO-2012017451-A1	Pratibha Omray, Vinay Kumar Tripathi	A bio-stabilized resveratrol formulation	A herbal medicament contains 50–80% RSV and other ingredients which helps to prevent and treat cancer, Alzheimer’s disease, obesity, and others.	[96]
US20110281957A1	Eric Kuhrts	Enhanced bioactive formulations of resveratrol	Enhanced solubility of RSV which is used for the treatment of disease states like cancer.	[97]
ES2798403T3	Dariush Behnam, Marshall A Hayward	Resveratrol solubilization product for pharmaceutical purposes	RSV solubilization product is used for pharmaceutical purposes and helps increase plasma level for therapeutics effects and also reduce GIT side effects as compared with natural RSV.	[98]
WO2001030336A2	John M. Pezzuto, Richard C. Moon, Mei-Shiang Jang, Aomar Ouali, Shengzhao Lin, Karla Slowing Barillas	Pharmaceutical formulations comprising resveratrol and use thereof	Designed the formulation for topical delivery which are helpful in preventing and treating the skin disorder caused by inflammation, sunburn, and aging.	[99]
WO2010059628A1	Arthur S. Polans, Lalita Subramanian, Ronak Vakil, Glen S. Kwon	Water-soluble formulations of resveratrol and uses thereof	Formulation of RSV with solubilizer poloxamer 334 and the solution can be used for the medicament of cancer.	[100]
CN104688715B	Wang Zhicheng, Zhu Kexin, Wang Bing, Cai Feng, Ren Jianlin, Zhang Tong, Zhang Qi, Zong Shiyu	A kind of resveratrol solid lipid nano granule and preparation method thereof	This invention helps to reduce particle diameter, drug loading and bioavailability is high and has fast absorption, and is convenient to take.	[101]
CN105126116B	Xiao Chunsheng, Chen Xin, Ding Jianxun, Zhuang Xiuli, Chen Xuesi	A kind of resveratrol nano particle and preparation method thereof	The formation of nanoparticle cross-linked structure with RSV increased water solubility and improved stability.	[102]
CN101214225A	Ouyang Wuqing, Yang Baoping	Resveratrol nano emulsion anti-cancer medicine	RSV nano emulsion increase half-life and stability and also prevent RSV to get oxygenated.	[103]

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Declarations

Acknowledgments

The authors are highly thankful to ISF College of Pharmacy, Moga for providing the necessary facilities for carrying out the review work.

Author contributions

AK and DS conceptualized the idea and prepared the first draft of the article. BDK and AS finalized the draft and approved it for final submission. DS submit the first draft of the article to the journal.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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