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Table 4

From: Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation

Table 4. LncRNAs and the m6A modification (interaction with writers, readers, erasers)

LncRNA	Interaction	Modified	Effect	Reference
FEZF1-AS1	IGF2BP1 sequestration	m6A	Apoptosis	[121]
DARS-AS1	METTL3-METTL14	m6A	Proliferation	[86]
THOR	Readers YTHDF1, YTHDF2	m6A	Oncogenesis	[122]
LNCAROD	METTL3-METTL14	m6A	Prevents YBX1 degradation	[123]
GAS5	Reader YTHDF3	m6A	GAS5 degradation	[124]
LINC02747	Reader YTHDF3	m6A	GAS5 degradation	[125]
LINC021	IGF2BP2	m6A	MSX1 stability	[126]
LINCRIS	Stabilization of IGF2BP2	m6A	Prevents K139 ubiquitination	[127]
DANCR	IGF2BP2 stabilizes the mRNA	m6A	-	[127]
LINC00958	METTL3 stabilizes mRNA	m6A	Inhibits degradation	[126]
KCNK15-AS1 downregulated	ALKBH5 eraser	m6A	Stabilization	[127]
LINC0047	METTL3	m6A	PTEN-m6A degradation	[126]
CASC11	ALKBH5	m6A	Decrease m6A UBE2T	[129]
CASC11	YTHDF2	m6A	Inhibits the association between UBE2T mRNA and m6A reader protein YTHDF2	[129]
ARHGAP5-AS1	METTL3	m6A	Stabilized by m6A	[126]
NEAT1_2	ALKBH5, YTHDF2	m6A	Destabilize mRNA	[130]
LINC00022	FTO	m6A	Block degradation by YTHDF2.	[126]
PVT1	Silencing ALKBH5	m6A	Decrease levels	[131]
CHASERR	METTL3/YTHDF1	m6A	Overexpressed	[132]
LEAWBIH	YTHDC1	m6A	Recruits H3K9me2 demethylase KDM3B	[133]
FTO-IT1	Recruits ILF2/ILF3 protein complex to 3’UTR of FTO mRNA, induced FTO stabilization	m6A	Decreased m6A modification on GLUT1, PKM2, c-MYC, alleviating YTHDF2-mediated mRNA degradation	[134]
MALAT1	Serine/arginine-rich splicing factor TRA2A forms a complex with writers METTL14, RBMX, KIAA1429	m6A	lncRNA m6A methylation	[135]

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CASC11: Cancer susceptibility 11; CHASERR: CHD2 adjacent suppressive regulatory RNA; MALAT1: metastasis-associated lung adenocarcinoma transcript 1; PVT1: plasmacytoma variant translocation 1; IGF2BP1: insulin growth factor 2 mRNA binding protein 1; METTL3: methyltransferase-like 3; YTHDF1: YT521-B homology domain family 1; ALKBH5: AlkB homolog 5; FTO: fat mass- and obesity-associated protein; TRA2A: transformer 2 alpha homolog; YBX1: Y-box-binding protein 1; PTEN: phosphatase and tensin homolog; UBE2T: ubiquitin-conjugating enzyme E2T; -: blank cell

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PP: Writing—review and editing.

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The author declares that he has no conflicts of interest.

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