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    13articles Vol.5(2024) , Issue 3
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    Review
    Advancements and recent explorations of anti-cancer activity of chrysin: from molecular targets to therapeutic perspective
    In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant s [...] Read more.
    Abhilasha Sood ... Manoj Kumar
    Published: May 23, 2024 Explor Target Antitumor Ther. 2024;5:477–494
    DOI: https://doi.org/10.37349/etat.2024.00230
    This article belongs to the special issue Molecular Targeted Therapy for Cancer
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    Open Access
    Perspective
    Practical implications of androgen receptor inhibitors for prostate cancer treatment
    Antiandrogens have been used for the treatment of prostate cancer as a single agent or in combination with hormone deprivation therapy. New generation antiandrogens act like androgen receptor inhibi [...] Read more.
    Fabio Campodonico ... Carlo Introini
    Published: May 28, 2024 Explor Target Antitumor Ther. 2024;5:543–550
    DOI: https://doi.org/10.37349/etat.2024.00234
    This article belongs to the special issue Molecular Diagnosis and Personalized Therapy of Cancer
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    Open Access
    Original Article
    Evaluation of molecular effects associated with apoptosis, tumour progression, angiogenesis and metastasis by a novel combination of drugs with ormeloxifene in triple negative breast cancer cells
    Aim: To investigate the molecular effects of a novel combination [sertraline and plumbagin (comb) with ormeloxifene (Orm)] for anticancer activity in triple negative breast cancer cell line “MD [...] Read more.
    Shehna Sharaf ... Lakshmi S
    Published: June 11, 2024 Explor Target Antitumor Ther. 2024;5:551–567
    DOI: https://doi.org/10.37349/etat.2024.00235
    This article belongs to the special issue Innovative Strategies to Target Triple-negative Breast Cancer
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    Open Access
    Perspective
    Resistance to immune checkpoint inhibitors in colorectal cancer with deficient mismatch repair/microsatellite instability: misdiagnosis, pseudoprogression and/or tumor heterogeneity?
    Colorectal carcinoma (CRC) with deficiency of the deficient mismatch repair (dMMR) pathway/ microsatellite instability (MSI) is characterized by a high mutation load and infiltration of immune cells [...] Read more.
    Nicola Normanno ... Carmine Pinto
    Published: May 23, 2024 Explor Target Antitumor Ther. 2024;5:495–507
    DOI: https://doi.org/10.37349/etat.2024.00231
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    Open Access
    Original Article
    Cadmium nanocluster as a safe nanocarrier: biodistribution in BALB/c mice and application to carry crocin to breast cancer cell lines
    Aim: Metal nanoclusters are emerging nanomaterials applicable for drug delivery. Here, the toxicity and oxidative stress induction of divalent cationic cadmium (Cd2+) was compared with a Cd in th [...] Read more.
    Moslem Jafarisani ... S. Zahra Bathaie
    Published: May 28, 2024 Explor Target Antitumor Ther. 2024;5:522–542
    DOI: https://doi.org/10.37349/etat.2024.00233
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    Meta-Analysis
    Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis
    Background: This article is based on our previous research, which was presented at the 2023 ASCO Annual Meeting I and published in Journal of Clinical Oncology as Conference Abstract (JCO. 2023;4 [...] Read more.
    Yiwen Zhou ... Jieer Ying
    Published: June 17, 2024 Explor Target Antitumor Ther. 2024;5:568–580
    DOI: https://doi.org/10.37349/etat.2024.00236
    This article belongs to the special issue Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
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    Open Access
    Review
    Management of oligometastatic and oligoprogressive epidermal growth factor receptor mutated non-small cell lung cancer patients: state of the art of a combined approach
    Recently, the development of targeted therapy approaches such as those based on tyrosine kinase inhibitor (TKI) greatly improved the clinical outcomes of patients affected by oncogene addicted advan [...] Read more.
    Francesca Di Pressa ... Alessio Bruni
    Published: May 17, 2024 Explor Target Antitumor Ther. 2024;5:449–464
    DOI: https://doi.org/10.37349/etat.2024.00228
    This article belongs to the special issue Integrated Approaches for Non-Small-Cell Lung Cancer
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    Open Access
    Perspective
    Immunotherapy in thymic epithelial tumors: tissue predictive biomarkers for immune checkpoint inhibitors
    Thymic epithelial tumors (TETs) are rare malignant neoplasms arising in the thymus gland. Nevertheless, TETs, including thymomas (TMs), thymic carcinomas (TCs), and thymic neuroendocrine neoplasms ( [...] Read more.
    Stefano Lucà ... Renato Franco
    Published: May 21, 2024 Explor Target Antitumor Ther. 2024;5:465–476
    DOI: https://doi.org/10.37349/etat.2024.00229
    This article belongs to the special issue Molecular Diagnosis and Personalized Therapy of Cancer
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    Open Access
    Original Article
    Chemotherapy related changes in cfDNA levels in squamous non-small cell lung cancer: correlation with symptom scores and radiological responses
    Aim: There is limited data on prognostic value of baseline plasma cell free DNA (cfDNA) in advanced squamous non-small cell lung cancer (sq-NSCLC). This prospective observational study aimed to a [...] Read more.
    Nithiyanandan Ravi ... Navneet Singh
    Published: May 28, 2024 Explor Target Antitumor Ther. 2024;5:508–521
    DOI: https://doi.org/10.37349/etat.2024.00232
    This article belongs to the special issue The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
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    Open Access
    Review
    Comparison of primary and passaged tumor cell cultures and their application in personalized medicine
    Passaged cell lines represent currently an integral component in various studies of malignant neoplasms. These cell lines are utilized for drug screening both in monolayer cultures or as part of thr [...] Read more.
    Vladislava V. Pipiya ... Valeriya V. Solovyeva
    Published: June 17, 2024 Explor Target Antitumor Ther. 2024;5:581–599
    DOI: https://doi.org/10.37349/etat.2024.00237
    View:95
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    Review
    Landscape of targeted therapies for advanced urothelial carcinoma
    Bladder cancer (BC) is the tenth most common malignancy globally. Urothelial carcinoma (UC) is a major type of BC, and advanced UC (aUC) is associated with poor clinical outcomes and limited surviva [...] Read more.
    Shihao Shang ... Zheng Zhu
    Published: June 21, 2024 Explor Target Antitumor Ther. 2024;5:641–677
    DOI: https://doi.org/10.37349/etat.2024.00240
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
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    Open Access
    Original Article
    Evaluation of antitumor potential of an anti-glypican-1 monoclonal antibody in preclinical lung cancer models reveals a distinct mechanism of action
    Aim: The main objective of this study was to investigate the antitumor effect of a mouse anti-human glypican-1 (GPC1) monoclonal antibody (mAb) on non-small cell lung carcinoma (NSCLC) and associ [...] Read more.
    Minghua Li ... Qingyu Zhou
    Published: June 17, 2024 Explor Target Antitumor Ther. 2024;5:600–626
    DOI: https://doi.org/10.37349/etat.2024.00238
    This article belongs to the special issue Molecular Diagnosis and Personalized Therapy of Cancer
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    Open Access
    Review
    Clinical relevance of circulating tumor DNA in ovarian cancer: current issues and future opportunities
    Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. Due to the lack of effective screening and early detection strategies, many patients with OC are diagnosed with advanced dise [...] Read more.
    Elena Trevisi ... Ilaria Colombo
    Published: June 19, 2024 Explor Target Antitumor Ther. 2024;5:627–640
    DOI: https://doi.org/10.37349/etat.2024.00239
    This article belongs to the special issue The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
    View:67
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    Times Cited: 0