Facial asymmetry for stroke (e.g., > 0.5°C abnormal; specific sensitivities 33–56% for Wallenberg syndrome); subtle temperature differences for skin cancer (e.g., Δ 2–4 K for melanoma)
Ranges reflect variations due to protocols and equipment; all p-values < 0.05 were reported [6, 7, 12]. For RA and other conditions, focus is on correlation and qualitative metrics rather than direct sensitivity, with significant associations (e.g., p < 0.05) as per [14, 24, 25]. AI: artificial intelligence; DAS28: Disease Activity Score 28, a validated index for RA disease activity discussed in the main text.
Declarations
Acknowledgments
This research was conducted as part of the Postgraduate Program in Insurance Medicine at the Faculty of Medicine, University of Porto.
Author contributions
EMF: Conceptualization, Methodology, Investigation, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.
Conflicts of interest
The author declares that there are no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
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References
Abdulkareem AF, Hashim AQ. Infrared medical thermography, medical applications, and its basic principles: A review.BIO Web Conf. 2024;97:1–35. [DOI]
Amin MA, Shah R, Tummala H, Ray I. Utilizing blockchain and smart contracts for enhanced fraud prevention and minimization in health insurance through multi-signature claim processing. In: Proceedings of the 2024 IEEE International Conference on Emerging Technologies in Computing and Communications (ETNCC); 2024 Jul 23–25; Windhoek, Namibia. IEEE; 2024. pp. 1–9. [DOI]
Chen X, Cao F, Wang Q, Ye Z. 2024 Chinese guideline on the construction and application of medical blockchain.Intell Med. 2025;5:73–83. [DOI]
Herington J, McCradden MD, Creel K, Boellaard R, Jones EC, Jha AK, et al. Ethical Considerations for Artificial Intelligence in Medical Imaging: Deployment and Governance.J Nucl Med. 2023;64:1509–15. [DOI] [PubMed]
International Association of Insurance Supervisors. Global Insurance Market Report (GIMAR). Basel: International Association of Insurance Supervisors; 2024.
Kesztyüs D, Brucher S, Wilson C, Kesztyüs T. Use of Infrared Thermography in Medical Diagnosis, Screening, and Disease Monitoring: A Scoping Review.Medicina (Kaunas). 2023;59:2139. [DOI] [PubMed] [PMC]
Khandakar A, Chowdhury MEH, Ibne Reaz MB, Md Ali SH, Hasan MA, Kiranyaz S, et al. A machine learning model for early detection of diabetic foot using thermogram images.Comput Biol Med. 2021;137:104838. [DOI] [PubMed]
Kostrub OO, Shukalo OI, Dunaevskyi VI, Kotovskyi VY, Tymofieiev VI, Nazarchuk SS. Remote infrared thermography in the system of comprehensive diagnostics of the health of military personnel before surgical intervention.Orthop Traumatol Prosthet. 2025;1:5–12. [DOI]
Kumar P, Gaurav A, Rajnish RK, Sharma S, Kumar V, Aggarwal S, et al. Applications of thermal imaging with infrared thermography in Orthopaedics.J Clin Orthop Trauma. 2021;24:101722. [DOI] [PubMed] [PMC]
Kurkela O, Lahtela J, Arffman M, Forma L. Infrared Thermography Compared to Standard Care in the Prevention and Care of Diabetic Foot: A Cost Analysis Utilizing Real-World Data and an Expert Panel.Clinicoecon Outcomes Res. 2023;15:111–23. [DOI] [PubMed] [PMC]
Magalhaes C, Mendes JG, Vardasca R. Meta-Analysis and Systematic Review of the Application of Machine Learning Classifiers in Biomedical Applications of Infrared Thermography.Appl Sci. 2021;11:842. [DOI]
Wu L, Huang R, He X, Tang L, Ma X. Advances in Machine Learning-Aided Thermal Imaging for Early Detection of Diabetic Foot Ulcers: A Review.Biosensors (Basel). 2024;14:614. [DOI] [PubMed] [PMC]
Nowakowski AZ, Kaczmarek M. Artificial Intelligence in IR Thermal Imaging and Sensing for Medical Applications.Sensors (Basel). 2025;25:891. [DOI] [PubMed] [PMC]
Podlasek A, Petrov I, Stankov Z, Snyder K, Alvarez CA, Musialek P, et al. Thermography in Stroke-A Systematic Review.Medicina (Kaunas). 2025;61:854. [DOI] [PubMed] [PMC]
Ramirez-GarciaLuna JL, Bartlett R, Arriaga-Caballero JE, Fraser RDJ, Saiko G. Infrared Thermography in Wound Care, Surgery, and Sports Medicine: A Review.Front Physiol. 2022;13:838528. [DOI] [PubMed] [PMC]
Rana SK, Rana SK, Nisar K, Ag Ibrahim AA, Rana AK, Goyal N, et al. Blockchain Technology and Artificial Intelligence Based Decentralized Access Control Model to Enable Secure Interoperability for Healthcare.Sustainability. 2022;14:9471. [DOI]
Raza AA, Arora B, Irfan MT. Securing Health Insurance Claims with Decentralization and Transparency: A blockchain-based Approach.Procedia Comput Sci. 2025;259:1918–26. [DOI]
Reed CL, Saatchi R, Ramlakhan S. Infrared thermal imaging for bone fracture identification and monitoring of fracture healing: A review of the latest developments. In: Proceedings of The Seventeenth International Conference on Condition Monitoring and Asset Management – CM 2021; The British Institute of Non-Destructive Testing; 2021.
Russo-Spena T, Mele C, Cavacece Y, Ebraico S, Dantas C, Roseiro P, et al. Enabling Value Co-Creation in Healthcare through Blockchain Technology.Int J Environ Res Public Health. 2022;20:67. [DOI] [PubMed] [PMC]
Schanz KU. Healthcare in Emerging Markets: Exploring the Protection Gaps. Zurich: The Geneva Association; 2019.
Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both.BMJ. 2017;358:j4008. [DOI] [PubMed] [PMC]
Sillero-Quintana M, Gómez-Carmona PM, Fernández-Cuevas I. Infrared thermography as a means of monitoring and preventing sports injuries.In: Innovative Research in Thermal Imaging for Biology and Medicine. IGI Global; 2017:165–98. [DOI]
Swiss Re Institute. Growth in the shadow of (geo)politics: global economic and insurance market outlook 2025–26. Zurich: Swiss Re Institute; 2024.
Tan YK, Hong C, Li H, Allen JC Jr, Thumboo J. A novel use of combined thermal and ultrasound imaging in detecting joint inflammation in rheumatoid arthritis.Eur J Radiol. 2021;134:109421. [DOI] [PubMed]
Verstockt J, Verspeek S, Thiessen F, Tjalma WA, Brochez L, Steenackers G. Skin Cancer Detection Using Infrared Thermography: Measurement Setup, Procedure and Equipment.Sensors (Basel). 2022;22:3327. [DOI] [PubMed] [PMC]