Laboratory assessment across clinical forms of hypophosphatasia treated with asfotase alfa.
| Test | Perinatal/Infantile | Childhood and adult |
|---|---|---|
| ALP | Baseline, 3, 6, 12 months and then every 6 months | Baseline, 2 weeks, 3, 6, 12 months and then annually |
| Plasma PLP, calcium, phosphate, urine PEA | Baseline, 1, 3, 6, 12 months and then annually | Baseline, 3 months and then annually |
| 25OHD | Baseline, 1, 3, 6, 12 months and then annually once normal levels are reached | Baseline, 3, 6, 12 months and then annually once normal levels are reached |
| PTH | Baseline and periodically based on calcium metabolism | Baseline and periodically based on calcium metabolism |
| Routine blood tests (CBC, liver function, electrolytes) | Baseline, 3, 6, 9, 12 months and then annually | Baseline, 6 months and then annually |
| Renal panel (creatinine, BUN) | Baseline and every 3 months | Baseline, 6 months and then annually |
| Anti-asfotase alfa antibodies (IgG) | As clinically indicated and available | As clinically indicated and available |
MV: Conceptualization, Writing—original draft, Writing—review & editing, Validation. TG: Conceptualization, Writing—original draft, Writing—review & editing, Validation. RK: Conceptualization, Writing—original draft, Writing—review & editing, Validation, Supervision. JB: Conceptualization, Writing—original draft, Writing—review & editing, Validation, Supervision. All authors read and approved the submitted version.
JB has received consultancy and speaker fees from Alexion Pharmaceuticals. RK has received consultancy and speaker fees from Alexion. There are no restrictions on the writing or publication of this article. The other authors declare no other conflicts of interest.
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The primary data for this systematic review were sourced online from databases listed in the methods. Referenced articles are accessible on PubMed/MEDLINE, Scopus, and Google Scholar. Additional supporting data are available from the corresponding author upon request.
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