From:  Association of neutrophil-to-lymphocyte ratio with peripheral neuropathy in rheumatoid arthritis

 Incremental diagnostic value of NLR in discriminating peripheral neuropathy in rheumatoid arthritis (RA).

Model/SubgroupAUC
(95% CI)
P value vs. baseNRI
(95% CI)
IDI
(95% CI)
Overall cohort
Base model0.75 (0.69–0.81)---
Base model + NLR0.83 (0.77–0.89)< 0.0010.18 (0.07–0.29)0.06 (0.02–0.10)
Seropositive RA
Base model0.74 (0.67–0.81)---
Base model + NLR0.82 (0.75–0.88)< 0.0010.16 (0.05–0.27)0.05 (0.02–0.09)
Seronegative RA
Base model0.71 (0.62–0.80)---
Base model + NLR0.79 (0.71–0.86)0.0020.15 (0.04–0.26)0.04 (0.01–0.08)

Base model included CRP, DAS28-ESR score, disease duration, and serological status. Model discrimination was assessed using ROC curve analysis. NRI and IDI were calculated to evaluate the improvement in predictive performance after the inclusion of NLR. NLR: neutrophil-to-lymphocyte ratio; AUC: area under the receiver operating characteristic curve; CI: confidence interval; NRI: net reclassification improvement; IDI: integrated discrimination improvement; CRP: C-reactive protein; DAS28: 28-joint Disease Activity Score; ESR: erythrocyte sedimentation rate; ROC: receiver operating characteristic.