Table Info

Table 2.

Comparison between IFA and AFA

Parameters	AFA	IFA
Etiology	Mutations AAAS 12q13	Multifactorial Genetic? Environment?
Disease	Multisystemic	Esophagus
Frequency	5 times	1 time
Consanguinity	73.2%	15.2%
Disease transmission	Horizontal only siblings	Horizontal/vertical siblings
Prognosis	Autonomic abnormalities Adrenal insufficiency	Good
PD	Low long-term remission

?: not proven as an etiological factor (remains hypothetical)

Declarations

Author contributions

AT: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review & editing. FB: Resources, Formal analysis, Investigation, Visualization, Methodology, Writing—review & editing. MEAB: Resources, Investigation. ML: Resources, Investigation. NO: Resources, Investigation.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

An ethical approval was obtained and the protocol of the study was approved by the hospital ethical committee.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

The datasets of this study can be found in Tebaibia’s data base, and can be shared on demand.

Funding

Not applicable.

Copyright

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