Zebrafish genes of xenobiotic metabolizing CYPs in cyp1–3 families. Drug detoxifying CYPs mentioned in the text are listed in the table. Zebrafish gene and corresponding human gene are listed in the same row. Functional conservation needs to be tested

Gene familyZebrafish geneHuman geneFunction
CYP1cyp1a, cyp1b1, cyp1c1,2, cyp1d1CYP1A1,2, CYP1B1, CYP1D1PCatalyzing oxidative biotransformation of xenobiotics, dioxin-induced cardiovascular toxicity [14]
CYP2cyp2r1CYP2R1Microsomal vitamin D 25-hydroxylase [13]
-cyp2u1CYP2U1Catalyzing ω and ω-1 hydroxylation of fatty acids [13]
-cyp2n13, cyp2ps, cyp2v1, cyp2ad2,3,6CYP2J2Arachidonic acid epoxygenase [13]
-cyp2ksCYP2W1It is a tumor-specific CYP that oxidizes indole and chlorzoxazone, but not fatty acids [13]
-cyp2y3,4CYP2A/B/F/SDrug-metabolizing enzymes
CYP3cyp3a65CYP3A4Metabolism of various drugs
-cyp3c1–4CYP3A3,4,7Mediates the formation of 5-hydroxydiclofenac (5-OHDF) and 6β-hydroxytestosterone [15]
CYP4cyp4f43CYP4FOmega-hydroxylases of C16–C26 fatty acids [13]
-cyp4v7,8CYP4V2-

-: none