Exploration of Digestive Diseases

Table 3. Summary of the role and importance of vitamin D in GI disease.

Category	The role and importance of vitamin D
Implicated GI diseases	IBD, IBS, CRC, diverticular disease, celiac disease, many others
Role in the GI system	Enhances immune response, improves intestinal epithelial barrier integrity, promotes favorable microbiome diversity, and regulates intestinal proliferation
Sources	Diet, supplementation, sunlight
Recommended dosing	Not definitive; 2,000 IU to 40,000 IU weekly dosing escalation has shown positive therapeutic efficacy correlation without serious adverse reactions
Recommended serum 25(OH)D levels	Greater than 30 ng/mL

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CRC: colorectal cancer; GI: gastrointestinal; IBD: inflammatory bowel disease; IBS: irritable bowel syndrome.

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Author contributions

NBDA: Writing—original draft, Writing—review & editing, Project administration. TV: Writing—original draft. ECOIV: Writing—review & editing. DAJ: Conceptualization, Supervision, Project administration, Writing—review & editing. All authors read and approved the submitted version.

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The authors declare that there are no conflicts of interest.

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