Most frequently altered genes in BTCs

GeneType of alterationFrequencyReferences
IDHMutation6–36%[13]
FGFRFusion8–14%[1315]
TP53Substitution/indel27–59%[13, 14]
ARID1AMutation7–36%[13]
KRASSubstitution/indel12–42%[13, 14]
SMAD4Mutation21–30%[13]
CDKN2ADeletion19%[13]

CDKN2A: cyclin dependent kinase inhibitor 2A; indel: insertion-deletion mutation