Table Info

Table 2.

List of select pan-Bcl-2 or Mcl-1 specific inhibitors

Compound	Target proteins	References
Compounds that down regulate Mcl-1 expression
Flavopiridol	CDK	[93, 94]
Seliciclib	CDK	[95, 96]
Sorafenib	Kinases	[108]
Resveratrol	STAT transcription factors	[98]
BH3 mimetics
Pan-Bcl-2 inhibitors
GX15-070 (obatoclax)	Bcl-2, Mcl-1, Bcl-xl, Bcl-w, Bcl-B	[119–121]
Gossypol (AT-101)	Bcl-2, Mcl-1, Bcl-xl	[122, 123, 140]
BI-97C1 (sabutoclax)	Bcl-2, Mcl-1, Bcl-xl, Bfl-1	[88, 116, 118]
TW-37	Bcl-2, Mcl-1, Bcl-xl	[7, 110, 111]
Mcl-1-specific inhibitors
MIM1	Mcl-1	[110, 112, 113]
Maritoclax (marinopyrrole A)	Mcl-1	[68, 123, 126]
UMI-77	Mcl-1	[51, 127, 128]
AZD5991	Mcl-1	[17]
S63845	Mcl-1	[76]
AMG-176	Mcl-1	[66, 130, 131]
AMG-397	Mcl-1	[132]

Declarations

Acknowledgment

All the figures were created using the BioRender.com application.

Author contributions

PS reviewed the literature and prepared the manuscript draft. Both authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors have no potential or existing conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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