Table Info

Table 2.

Successful recent preclinical studies of TME targeting ADCs

Target	TME component	ADC	Payload	Tumour types	Translation to clinic
LRRC15	CAF	ABBV-085	MMAF	NSCLC, osteosarcoma, breast cancer, GBM	Phase I trial in sarcoma and other advanced solid tumours (published 2021) [113]
FAPα	CAF	OMTX705 (+ ICI)	TAM470 (MTI)	NSCLC, TNBC, ovarian, pancreatic	Pending
TEM8	Stroma	m825-MMAE	MMAE	CRC, breast, lung, ovarian, pancreatic	Pending
TF	Stroma	TF antibody-MMAE	MMAE	pancreatic	Phase II trial (TV) in refactaory cervical cancer—positive (published 2021) [127]
EphA3	Stroma	IIIA4-USAN	USAN	GBM	Pending

CAF: cancer associated fibroblast; Eph: erythropoietin-producing hepatocellular carcinoma; FAPα: fibroblast activating protein α; LRRC15: leucine-rich repeat containing 15; MTI: microtubule inhibitor; TEM8: tumour endothelial marker 8; TF: tissue factor; TV: tisotumab vedotin; USAN: maytansine; +: plus

Declarations

Author contributions

SM, SP and HKG contributed to the drafting and editing of the manuscript. SM created the figures. HKG contributed to conception and design of the review. All authors contributed to manuscript revision, read, and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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