Phase 2 basket, open-label, multicenter, global (STARTRK-2)
700 (estimated)
Recruiting
Ongoing
NCT02568267
Larotrectinib
Phase 2 basket (NAVIGATE)
203 (estimated)
Recruiting
Ongoing
NCT02576431
BRAF
Dabrafenib + trametinib
Phase 2, open-label
206
Active, not recruiting
ORR = 47%; mDoR ≥6 mos in the 54% of responders; PFS = 7.2 mos; OS = 11.3 mos (interim results for 43 pts)
NCT02034110
mPFS: median progression-free survival; DCR: disease control rate; mos: months; ORR: overall response rate; DoR: duration of response; mDoR: median duration of response; pts: patients
Declarations
Author contributions
MC: conceptualization and writing original draft; MC, AS, and LF: wrote sections of the manuscript. NN: conceptualization, visualization, supervision and writing-review and editing. All authors contributed to manuscript revision, read and approved the submitted version.
Conflicts of interest
NN: personal financial interests (speaker’s fees and/or advisory boards): MSD, QIAGEN, Bayer, Biocartis, Incyte, Roche, BMS, MERCK, Thermo Fisher, Boehringer Ingelheim, AstraZeneca, Sanofi, Eli Lilly, Illumina, and Amgen Institutional; financial interests (financial support to research projects): MERCK, Sysmex, Thermo Fisher, QIAGEN, Roche, AstraZeneca, Biocartis, and Illumina. NN: non-financial interests: President, International Quality Network for Pathology (IQN Path); President-Elect, Italian Cancer Society (SIC).
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