Exploration of Targeted Anti-tumor Therapy

Table 1. Summary of pharmacological inhibitors of TPC2 that have been pre-clinically evaluated in cancer

Name	Class	Structure
Naringenin	Flavonoid
Tetrandrine	Ca²⁺ channel blocker
Ned-19	NAADP-antagonist
Verapamil	Ca²⁺ channel blocker

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Structures obtained from PubChem [83].

Note. Structure image of Naringenin is reprinted from https://pubchem.ncbi.nlm.nih.gov/compound/932#section=2D-Structure; structure image of Tetrandrine is reprinted from https://pubchem.ncbi.nlm.nih.gov/compound/73078#section=2D-Structure; structure image of Ned-19 is reprint from https://pubchem.ncbi.nlm.nih.gov/compound/3978027#section=2D-Structure; structure image of Verapamil is adapted from https://pubchem.ncbi.nlm.nih.gov/compound/2520#section=2D-Structure

Declarations

Author contributions

All authors contributed to the drafting and editing of the manuscript. DLB and DZT created the figures. KAS and LFL contributed conception and design of the review. KAS, LFL, DLB and DZT contributed to manuscript revision, read, and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

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Funding

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Copyright

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