Summary of pharmacological inhibitors of TPC2 that have been pre-clinically evaluated in cancer
Name | Class | Structure |
---|---|---|
Naringenin | Flavonoid | ![]() |
Tetrandrine | Ca2+ channel blocker | ![]() |
Ned-19 | NAADP-antagonist | ![]() |
Verapamil | Ca2+ channel blocker | ![]() |
Structures obtained from PubChem [83].
Note. Structure image of Naringenin is reprinted from https://pubchem.ncbi.nlm.nih.gov/compound/932#section=2D-Structure; structure image of Tetrandrine is reprinted from https://pubchem.ncbi.nlm.nih.gov/compound/73078#section=2D-Structure; structure image of Ned-19 is reprint from https://pubchem.ncbi.nlm.nih.gov/compound/3978027#section=2D-Structure; structure image of Verapamil is adapted from https://pubchem.ncbi.nlm.nih.gov/compound/2520#section=2D-Structure
All authors contributed to the drafting and editing of the manuscript. DLB and DZT created the figures. KAS and LFL contributed conception and design of the review. KAS, LFL, DLB and DZT contributed to manuscript revision, read, and approved the submitted version.
The authors declare that they have no conflicts of interest.
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© The Author(s) 2022.