Exploration of Targeted Anti-tumor Therapy

Table 1. Additional phosphorus dendrimers used for gene delivery of siRNAs corresponding to Figure 7

Construction	R1	Studies	Reference
Plasmid and oligonucleotides	-Et	DNA delivery in HeLa and NIH 3T3 cells	[47]
Anti-HIV siRNA		siP24 delivery in HEK293 cells	[48]
siRNA (siPLK1)		Delivery in MDA-MB-231 (triple-negative breast cancer) and MCF-7 cells	[49]
Plasmid: green fluorescent protein (GFP) reporter gene		Transfection of human stromal/mesenchymal stem cells	[50]
G4 phosphorus dendrimer
Anti-TNFα siRNA		In vivo via nasal administration	[51]

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HIV: human immunodeficiency virus; PLK1: polo-like kinase 1; TNFα: tumor necrosis factor alpha

Declarations

Author contributions

All authors have contributed as follows: SM 25% writing, XS 25% writing, MB 10% writing, DS 15% writing, and JPM 25% writing. SM, XS and JPM wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Serge Mignani and Xiangyang Shi were granted by FCT-Fundação para a Ciência e a Tecnologia (Base Fund UIDB/00674/2020 and Programmatic Fund UIDP/00674/2020, Portuguese Government Funds) and ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação through the project M1420-01-0145-FEDER-000005-CQM + (Madeira 14–20 Program). Xiangyang Shi, Serge Mignani and Jean-Pierre Majoral were granted by the PRC NSFC-CNRS 2019 (21911530230 for Xiangyang Shi and 199,675 for Serge Mignani and Jean-Pierre Majoral). Jean-Pierre Majoral was granted by the CNRS for financial support. Dzmitry Shcharbin was granted by the NAWA International Academic Partnership Programme EUROPARTNER, PPI/APM/2018/1/00007/U/001, by the State Comission of Science and Technology of Belarus: projects B20SLKG-002, B21TUB-001, B21KORG-001, B21ARMG-002. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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