Table Info

Table 1.

Trials of approved checkpoint inhibitors for R/M HNSCC

Authors	Study	Setting	Study arm	Control arm	Median OS		Approval
Ferris et al. [5]	CheckMate-141	Platinum-resistant	Nivo	SoC	Nivo: 7.5 months SoC: 5.1 months		FDA EMA
Cohen et al. [4]	KEYNOTE-040	Platinum-resistant	Pembro	SoC	Pembro: 8.4 months SoC: 6.9 months		FDA EMA (TPS ≥ 50%)
Burtness et al. [11]	KEYNOTE-048^*	First-line	Pembro	EXTREME	PD-L1 CPS ≥ 20 Pembro: 14.9 months EXTREME: 10.8 months	PD-L1 CPS ≥ 1 Pembro: 12.3 months EXTREME: 10.4 months	FDA EMA
Burtness et al. [11]	KEYNOTE-048^*	First-line	Pembro + CT	EXTREME	PD-L1 CPS ≥ 20 Pembro + CT: 14.7 months EXTREME: 11.1 months	PD-L1 CPS ≥ 1 Pembro + CT: 13.6 months EXTREME: 10.6 months	FDA EMA

ESMO 2020 Congress update

Declarations

Author contributions

SC, DMF and LDL contributed conception and design of the study; DMF, AO and SC organized the tables; SC, DMF and LL wrote the first draft of the manuscript. All authors contributed to manuscript drafting, writing, and revision and fulfilled the criteria included in the ICMJE guidelines. All authors read and approved the submitted version.

Conflicts of interest

Laura D. Locati reports grant and other financial relationships with Eisai, Ipsen, Merck Serono, MSD, BMS, Lilly. Lisa Licitra declares the following conflicts of interests: receipt of grants/research supports (Funds received by my institution for clinical studies and research activities in which I am involved) from AstraZeneca, BMS, Boehringer Ingelheim, Celgene International, Debiopharm International SA, Eisai, Exelixis Inc, Hoffmann-La Roche Ltd, IRX Therapeutics inc, Medpace Inc, Merck-Serono, MSD, Novartis, Pfizer, Roche; receipt of honoraria or consultation fees (for public speaking/teaching in medical meetings and/or for expert opinion in advisory boards) from AstraZeneca, Bayer, BMS, Eisai, MSD, Merck-Serono, Boehringer Ingelheim, Novartis, Roche, Debiopharm International SA, Sobi, Ipsen, Incyte Biosciences Italy SRL, Doxa Pharma, Amgen, Nanobiotics Sa, and GSK. The remaining authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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