Table Info

Table 2.

Summary of ongoing clinical trials of PROTAC degraders

Target	PROTAC name	Types of clinical trials	Patient population	ClinicalTrials.gov number	Sponsor
AR	ARV-110	Phase 1/2	mCRPC	NCT03888612	Arvinas
AR	CC-94676	Phase 1	mCRPC	NCT04428788	Celgene/BMS
ER	ARV-471 alone or with palbociclib	Phase 1/2	ER⁺/HER2⁻ advanced or metastatic breast cancer	NCT04072952	Arvinas
BTK	NX-2127	Phase 1	Relapse/refractory B-cell malignancies	NCT04830137	Nurix Therapeutics
BCL-xL	DT2216	Phase 1	Relapse/refractory solid and hematologic malignancies	NCT04886622	Dialectic Therapeutics
BRD9	FHD-609	Phase 1	Advanced synovial sarcoma	NCT04965753	Foghorn Therapeutics

AR: androgen receptor; ER: estrogen receptor; BTK: Bruton’s tyrosine kinase; BCL-xL: B-cell lymphoma-extra large; BRD9: bromodomain-containing protein 9; mCRPC: metastatic castration resistant prostate cancer; HER2: human epidermal growth factor receptor 2

Declarations

Author contributions

HX, JL and DMAG wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

The support grant to Dr. Hao Xie was from H. Lee Moffitt Cancer Center & Research Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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