Table Info

Table 2.

Active trials, both recruiting and not recruiting, testing IDH and breast cancer gene (BRCA) inhibitors

NCT	Phase	Status	Tumors	Line of treatment	Target	Experimental treatment	Standard treatment	Primary endpoints	Sponsor
NCT04088188	1	Recruiting	CCA	1 L	IDH1	Ivosidenib + Cis-Gem	N.A.	DLT	Profit
NCT04521686	1	Recruiting	CCA	NTA	IDH1	LY3410738	N.A.	RP2D	Profit
NCT02381886	1	Active, not recruiting	CCA	UNK	IDH1	IDH305	N.A.	DLT	Profit
NCT03684811	1/2	Active, not recruiting	CCA	Phase 1: NTA Phase 2: 1	IDH1	Olutasidenib +/– Nivolumab or +/– Cis-Gem	N.A.	DLT, RP2D, ORR	Profit
NCT02273739	1/2	Completed	iCCA	NTA	IDH2	Enasidenib	N.A.	AEs, DLT	Profit
NCT02496741	1/2	Completed	iCCA	All	IDH1/2	Metformin + chloroquine	N.A.	MTD	No-profit
NCT03878095	2	Recruiting	CCA	NTA	IDH1/2 + PARP*	Ceralasertib + olaparib	N.A.	ORR	No-profit
NCT03212274	2	Recruiting	CCA	NTA	IDH 1/2	Olaparib	N.A.	ORR	No-profit
NCT03991832	2	Recruiting	CCA	1–2 L	IDH	Olaparib + durvalumab	N.A.	ORR, DCR	No-profit
NCT03207347	2	Recruiting	CCA	NTA	DDR mutation	Niraparib	N.A.	ORR	Profit
NCT04306367	2	Recruiting	CCA	2 L	PARP*	Pembrolizumab + olaparib	N.A.	ORR	No-profit
NCT01282333	1	Terminated	eCCA and gallbladder cancer	1 L	BRCA1/2	Veliparib + Cis-Gem	N.A.	MTD	No-profit

We also reported two trials defined as “completed” and another one defined as “terminated” on www.clinicaltrials.gov, whose results have never been published.

Not inclusion criteria; UNK: unknown; PARP: poly ADP-ribose polymerase; DDR: DNA damage repair

Declarations

Author contributions

MDM, DM, ES contributed conception and design of the review; AC, TG, FDV organized the database; GA, CP, CZ wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Massimo Di Maio received honoraria and had roles as consultant or advisor for AstraZeneca, Pfizer, Novartis, Roche, Takeda, Eisai, Janssen, Astellas; received institutional research grant by Tesaro e GlaxoSmithKline, outside the submitted work. All remaining authors declared no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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