Table Info

Table 1.

Active trials, both recruiting and not recruiting, with FGFR’s inhibitors described above

NCT	Phase	Status	Tumors	Line of treatment	Target	Experimental treatment	Standard treatment	Primary endpoints	Sponsor
NCT03656536	3	Recruiting	CCA	1 L	FGFR2 rearrangement	Pemigatinib	Gem-Cis	PFS	Profit
NCT03773302	3	Recruiting	CCA	1 L	FGFR2 fusions/translocations	Infigratinib	Gem-Cis	PFS	Profit
NCT04093362	3	Recruiting	iCCA	1 L	FGFR2 rearrangement	Futibatinib	Gem-Cis	PFS	Profit
NCT04256980	2	Active, not recruiting	CCA	2 L	FGFR2 rearrangement	Pemigatinib	N.A.	ORR	Profit
NCT04083976	2	Recruiting	CCA	≥ 2 L	FGFR mutations/fusions	Erdafitinib	N.A.	ORR	Profit
NCT03230318	2	Recruiting	iCCA	2 L	FGFR2 fusion, mutation or amplification	Derazantinib	N.A.	ORR	Profit
NCT04233567	2	Recruiting	CCA	≥ 2 L	FGFR fusions, translocations or activating mutations	Infigratinib	N.A.	ORR	Non-profit
NCT04238715	2	Recruiting	CCA	2 L	FGFR2 fusion	E7090	N.A.	ORR	Profit
NCT04353375	2	Not yet recruiting	iCCA	2 L	FGFR2 fusion	HMPL-453 tartrate	N.A.	ORR	Profit
NCT04565275	1/2	Recruiting	CCA	NTA	FGFR alteration	ICP-192	N.A.	MTD, ORR, AE, OBD, RP2D	Profit
NCT03144661	1	Terminated	CCA	NTA	FGF19/FGFR4	INCB062079	N.A.	Safety	Profit
NCT04149691	1	Recruiting	CCA	NTA	FGFR 1, 2, 3 alteration	CPL304110	N.A.	MTD, safety	Profit
NCT03583125	1	Recruiting	CCA	NTA	FGFR alteration	EOC317	N.A.	DLT	Profit
NCT04526106	1	Recruiting	CCA	NTA	FGFR2 fusion, mutation, or amplification	RLY-4008	N.A.	MTD, AE	Profit

A “withdrawn” trial was excluded, stopped early because of a slow accrual (NCT04479904). AE: adverse event; DLT: dose-limiting toxicity; MTD: maximum tolerated dose; NTA: no treatment available; OBD: optimal biological dose; PFS: progression-free survival; RP2D: recommended phase 2 dose; L: chemotherapy line; N.A.: not applicable

Declarations

Author contributions

MDM, DM, ES contributed conception and design of the review; AC, TG, FDV organized the database; GA, CP, CZ wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Massimo Di Maio received honoraria and had roles as consultant or advisor for AstraZeneca, Pfizer, Novartis, Roche, Takeda, Eisai, Janssen, Astellas; received institutional research grant by Tesaro e GlaxoSmithKline, outside the submitted work. All remaining authors declared no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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