Nociceptive TRP channels respond to environmental stimuli

Environmental stimuliCategoryNociceptive TRP channelReference
MicrobesGram-negative bacteria: bacterial endotoxinsTRPA1, TRPM3, TRPM8, TRPV1[81]
OncovirusEBVTRPA1[82]
HBVTRPC6[83]
HPVTRPV4[84]
ChemicalsMustard oil, formalinTRPA1[85]
Menthol, icilinTRPM8
DEHPTRPV1[86]
Particulate matterTRPA1, TRPC6, TRPM2, TRPV1, TRPV4[20]
Physical injuriesMechanical gatingTRPA1, TRPC1, TRPC3, TRPC6, TRPM8[87]
UVATRPA1[88]
UVBTRPC7[13]

EBV: Epstein-Barr virus; HBV: hepatitis B virus; HPV: human papilloma virus; UVA: ultraviolet A