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From: A novel strategy for treating cancer: understanding the role of Ca²⁺ signaling from nociceptive TRP channels in regulating cancer progression

Table 1. Nociceptive TRP channels respond to environmental stimuli

Environmental stimuli	Category		Nociceptive TRP channel	Reference
Microbes	Gram-negative bacteria: bacterial endotoxins		TRPA1, TRPM3, TRPM8, TRPV1	[81]
	Oncovirus	EBV	TRPA1	[82]
		HBV	TRPC6	[83]
		HPV	TRPV4	[84]
Chemicals	Mustard oil, formalin		TRPA1	[85]
	Menthol, icilin		TRPM8
	DEHP		TRPV1	[86]
	Particulate matter		TRPA1, TRPC6, TRPM2, TRPV1, TRPV4	[20]
Physical injuries	Mechanical gating		TRPA1, TRPC1, TRPC3, TRPC6, TRPM8	[87]
	UVA		TRPA1	[88]
	UVB		TRPC7	[13]

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EBV: Epstein-Barr virus; HBV: hepatitis B virus; HPV: human papilloma virus; UVA: ultraviolet A

Declarations

Author contributions

WLH, writing—original draft preparation; MN, review and editing; EI, review and editing; TY, supervision.

Conflicts of interest

The authors declare no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by Ministry of Science and Technology of Taiwan, MOST 109-2314-B-037-143. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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