Chemosensitizing potential of PL

DrugsCancerIn vitro/In vivoModelMechanismReferences
BortezomibMMIn vitroNCI-H929↑Apoptosis, ↓p-STAT3[110]
CisplatinHNCIn vitroAMC-HN2, -HN3, -HN4, -HN6, -HN7, -HN8, SNU-1041, -1066, -1076, HN30, HN31, UMSCC1, 93-VU-147T↑ROS, ↓GSH, ↑GSSG, ↑PUMA, ↑cleaved PARP, ↑p-JNK, ↓GSTP1, -HN9, ↑p-p53 (Ser 15), ↑apoptosis[149]
In vivoAMC-HN2 & -HN9, xenograft↓Tumor growth, ↑p53, ↑apoptosis[149]
DoxorubicinProstate cancerIn vitroDU-145↑Apoptosis, ↑caspase-3, ↑cleaved PARP[148]
5-FlurouracilOral cancerIn vitroSAS, CGHNC8↓Cell viability, ↓survival[144]
GemcitabinePancreatic cancerIn vitroBxPC-3, PANC-1, AsPC-1↑Apoptosis, ↓NF-κB[115]
In vivoBxPC-3 xenograft↓Tumor burden, ↑apoptosis, ↓NF-κB[115]
OxaliplatinGastric cancerIn vitroSGC-7901, AGS, BGC-823↓TrxR1 activity, ↑ROS, ↑apoptosis, Activation of p38 and JNK signaling pathways, ↑γ-H2A.X[147]
In vivoSGC-7901 xenograft↓Tumor growth, ↓TrxR1 activity[147]
PTXIntestinal CancerIn vitroINT-407 and HCT-116↓Proliferation[127]

GSSG: GSH disulphide; p: phosphorylated