Representative studies about Ca2+ channels/pumps/uniporters in cancer metastasis

Channels/Pumps/UniportersAlterationEvents/MechanismsCancer typeReference
VGCCCav1.2-CRC[143]
Cav1.3-Breast cancer, endometrial carcinoma[144, 145]
Cav2.2EMTBreast cancer[146]
Cav3.1/3.2--Glioblastoma, RAFV600E melanoma[147, 148]
CRAC--Upregulation of MFAP5 derived from CAFs increases SOCE in cancer cellsOvarian cancer[149]
Orai1Focal adhesion turnover, invadopodium formation, EMT and extracellular matrix degradationGlioma, melanoma and breast cancer[13, 150153]
Orai2Focal adhesion disassemblyGC[154]
Orai3-Neuroendocrine-to-mesenchymal transitionGastro-enteropancreatic neuroendocrine tumor[151]
STIM1Focal adhesion turnover and invadopodium formationMelanoma, gastric and breast cancer[13, 153, 155]
STIM2EMTBreast cancer[8]
MS4A12-Colon cancer[156]
TRP channelTRPC1EMTBreast cancer[157]
TRPC3-Melanoma[158]
TRPC4--Medulloblastoma[159]
TRPC5EMTColon cancer[160]
TRPC6EMTBreast and gastric cancer[161163]
TRPM2-EMTGastric cancer[164]
TRPM3EMTRenal cell carcinoma[165]
TRMP4EMTProstate cancer[166, 167]
TRPM5-MMP9Melanoma[168]
TRPM7EMTNasopharyngeal carcinoma, ovarian and breast cancer[169171]
TRPM8EMTColon cancer[172]
TRPML1-Lysosomal exocytosisHepatocellular carcinoma[173]
TRPP2EMTLaryngeal squamous cell carcinoma[174]
TRPV1Peritoneal disseminationGC[175]
TRPV2-Prostate and esophageal cancer[176]
TRPV4Matrix stiffness and EMTEndometrial and breast cancer[177, 178]
Tumor vessel integrityProstate cancer[179]
TRPV5-Renal cell carcinoma[180]
TRPV6-Prostate cancer[181]
ATP dependent pumpsPMCA4EMTGC[182]
SERCA-Focal adhesionsGlioblastoma[183]
SERCA2-Colorectal cancer[184]
SERCA3-Colorectal adenoma-adenocarcinoma[185]
P2X7EMT and formation of filopodiaMelanoma and colon cancer[186188]
P2Y--Colon cancer[187]
P2Y2-EMTProstate cancer[189, 190]
P2Y6-Filopodia and focal adhesionsLung cancer[191]
P2Y12-Positive regulation of Akt in platelets-[192]
MCU complexEMRE-TNBC[193]
MCUROS, MVD, tube formation and sprouting capacityHepatocellular carcinoma and TNBC[194196]
MCUbROSTNBC[196]
MICU1ROSTNBC[193]
ROSHepatocellular carcinoma[194]
MICU2ROSTNBC[193]
MCUR1EMTHCC[197]
TPCsTpc2EMTMelanoma[198]
IP3RIP3R-3-Colorectal cancer[199]
RyRRyR2-Thyroid carcinoma[200]

↑: indicates increased; ↓: indicates decreased; -: indicates not availab; VGCC: voltage-gated Ca2+ channel; MFAP5: microfibrillar-associated protein 5; SOCE: store-operated Ca2+ entry; STIM: stromal interaction molecule; TRP: transient receptor potential; TRPC: TRP canonical; TRPM: TRP melastatin; TRPML1: Mucolipin TRP channel 1; TRPP2: TRP polycystin 2; TRPV: TRP vanilloid; PMCA: plasma membrane Ca2+ ATPase; GC: gastric cancer; SERCA: (Sarco)-ER Ca2+ ATPase; MCU: mitochondrial calcium uniporter; EMRE: essential MCU regulator; MCUb: MCU dominant negative beta subunit; MICU: mitochondrial calcium uptake; MCUR1: MCU regulator 1; TPC: two-pore channel; IP3R: inositol 1,4,5-trisphosphate receptor; RyR: ryanodine receptor; MVD: microvessel density