From:  Redefining axillary management by selecting patients for omission of sentinel lymph node surgery in early breast cancer

 NNS to identify one additional patient eligible for CDK4/6 inhibitor.

Clinical scenarioCDK4/6 strategyEligibility dependent on LN statusNNS
T1Ribociclib7.5–8.1%13
Abemaciclib2.1–2.2%45–48

The estimates presented are derived from published data [35, 37]. For abemaciclib, the estimates are based on FDA-approved eligibility criteria. They are intended to illustrate the potential clinical implications of nodal staging. They have not been prospectively validated and should not be interpreted as predictive estimates. NNS: number needed to stage; CDK4/6: cyclin-dependent kinase 4 and 6; LN: lymph node.