1 All indications refer to advanced, HR+/HER2– breast cancer; 2 the five most common AEs are listed; ties at 5th rank are all included; 3 death due to right ventricular failure; 4 for Camizestrant (SERENA-2 trial), incidence of specific AEs and treatment-related AEs were not reported. Therefore, treatment-emergent AEs (TEAEs) are listed instead. Definition of treatment-emergent AE (from SERENA-2 protocol): events will be defined as treatment-emergent if they onset or worsen during the treatment period or safety follow-up period; 5 numerous ≥ G3 TEAEs each occurred in only a single patient; these individual events are not listed for clarity. AE: adverse event; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CDK4/6i: CDK4/6 inhibitor; EMA: European Medicines Agency; ET: endocrine therapy; FDA: Food and Drug Administration; G: grade; HER2–: HER2-negative; HR+: hormone receptor-positive.
Declarations
Acknowledgments
During the preparation of this work, the authors used Claude (Anthropic, Opus 4.8) and ChatGPT (OpenAI, GPT-5.3) for language refinement, improvement of readability, and translation of selected expressions. After using the tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.
Author contributions
AMH: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. RB: Conceptualization, Investigation, Supervision, Visualization, Writing—original draft, Writing—review & editing. Both authors read and approved the submitted version.
Conflicts of interest
AMH received travel support from Janssen and Amgen. RB received honoraria from H+O Health Communications, Medtis, Novartis, AstraZeneca, Impulze, Janssen, Silamed, Daiichi-Sankyo, Gilead, Stemline Menarini, MSD, OncoPulse; research funding from Gilead; travel support from Daiichi-Sankyo, Astra Zeneca, Servier and Roche; is a mentee in the ENDEAVOUR-Breast program; his wife is employed by CSL Behring AG; and he is listed on a patent application (provisional application no. 63/503,528) submitted to Massachusetts General Hospital.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study received Institutional Funding from the Department of Medical Oncology and the Medical Faculty of the University of Bern. The funders had no role in the conception and conduct of the review, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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