Exploration of Targeted Anti-tumor Therapy

Table 3. Treatment strategies.

Question	Main responses	Consensus status
Should local therapies be prioritized in oligoprogressive disease occurring under effective systemic therapy?	Context-dependent: 6 (60%) Always: 4 (40%)	Relative agreement
Which local therapy is preferred for oligoprogressive disease?	Any modality depending on site: 6 (60%) Radiotherapy (SBRT/SABR): 4 (40%)	Relative agreement
If radiation therapy is chosen, is there a preferred regimen?	SBRT/SABR: 8 (80%) No preference: 2 (20%)	Consensus
Should systemic therapy be continued during oligoprogressive disease if effective?	Yes: 8 (80%) No: 2 (20%)	Consensus
For repeat oligoprogression, what management strategy is appropriate?	Local + systemic switch: 6 (60%) Local + continue systemic therapy: 4 (40%)	Relative agreement

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SBRT: stereotactic body radiation therapy; SABR: stereotactic ablative body radiotherapy.

Declarations

Acknowledgments

The consensus committee would like to thank all the experts who took part in developing the consensus.

Author contributions

DK: Supervision, Writing—original draft, Project administration, Investigation. IO: Investigation, Writing—review & editing. SK: Investigation, Writing—review & editing. NO: Investigation, Writing—review & editing. MD: Investigation, Writing—review & editing. EU: Investigation, Writing—review & editing. DA: Investigation, Writing—review & editing. BB: Investigation, Writing—review & editing. IT: Supervision, Writing—original draft, Project administration, Investigation. TM: Supervision, Writing—original draft, Project administration, Investigation. All authors, as committee members, participated in the preparation of the meeting results questionnaire, data discussion, and article approval.

Conflicts of interest

The authors have no conflicts of interest.

Ethical approval

This study was based exclusively on an anonymous survey of expert opinions and did not involve human participants, patient data, biological specimens, or animal research. Therefore, institutional review board (IRB) or ethics committee (Asfendiyarov Kazakh National Medical University) approval was not required under applicable national regulations.

Consent to participate

Informed consent (including for publication) was obtained from all individual participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

The data supporting the findings of this study are available from the corresponding author upon reasonable request.

Funding

The work was carried out within the framework of the budgetary funding of the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan [BR24992933] “Development and Implementation of Diagnostic Models, Treatment, and Rehabilitation Techniques for Cancer Patients.” The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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