From:  Distinct transcriptomic features of tumor and stromal cells in direct contact in luminal and triple-negative breast cancers

 Ligand-receptor pairs in the colocalization regions of tumor and stromal cells in luminal and triple-negative breast cancer (BC): (I) common pairs for luminal and triple-negative BC, (II) pairs unique to luminal BC, (III) pairs unique to triple-negative BC.

LigandReceptorCells expressing ligandCells expressing receptorFunctionReferences
I. Luminal and triple-negative BC
CDH1CDH1tumor cellstumor cellsepithelial cells adhesion, EMT regulation[19, 20]
CDH1ITGA2_ITGB1tumor cellstumor cellscell-cell adhesion[21]
HLA-DMACD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DMBCD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DQA1CD4tumor cells, APCsT cellsantigen presentation[22]
OCLNOCLNtumor cellstumor cellstight junctions[23]
II. Luminal BC
APPCD74tumor cellsmacrophagessuppressing the phagocytic activity of macrophages[24]
CD46JAG1T cellsepithelial cells, endothelial cellsinduction of T helper 1 effector T cells and their switching into regulatory T cells[25, 26]
CD99CD99L2tumor cells, immune cellstumor cells, immune cellsadhesion, transendothelial migration, differentiation, cell death[27]
CDH5CDH5tumor cells, endothelial cellstumor cells, endothelial cellsepithelial cells, endothelial cells adhesion[28]
DSC2DSG2tumor cellstumor cellsformation of desmosomes[29]
DSG2DSC3tumor cellstumor cellsformation of desmosomes[29]
ENTPD1ADORA1tumor cells, endothelial cells, immune cellsimmune cellsactivating immune suppressor cells[30]
HLA-DPA1CD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DPB1CD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DRACD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DRB1CD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DRB5CD4tumor cells, APCsT cellsantigen presentation[22]
HLA-DOACD4tumor cells, APCsT cellsantigen presentation[22]
ICAM1ITGAX_ITGB2tumor cells, endothelial cells, immune cellsimmune cellsstabilizing cell-cell interactions and promoting leukocyte-endothelial migration[31]
ICAM1ITGAM_ITGB2tumor cells, endothelial cells, immune cellsimmune cellsstabilizing cell-cell interactions and promoting leukocyte-endothelial migration[31]
ITGA9_ITGB1VCAM1tumor cellsendothelial cells, tumor cellscell adhesion, migration[32, 33]
ITGA4_ITGB7VCAM1leukocytesendothelial cells, tumor cellsrolling and firm adhesion[32]
ITGA4_ITGB1VCAM1leukocytesendothelial cells, tumor cellsrolling and firm adhesion[32]
ITGB2ICAM1leukocytestumor cells, endothelial cells, immune cellsleukocyte trafficking and adhesion[34]
JAM2ITGAV_ITGB1tumor cells, endothelial cells, leukocytesimmune cellsleukocyte trafficking[35]
JAM2ITGA3_ITGB1tumor cells, endothelial cells, leukocytesimmune cellsleukocyte trafficking[35]
JAM3ITGAM_ITGB2tumor cells, endothelial cells, leukocytesimmune cellsleukocyte trafficking[36]
JAM2JAM2tumor cells, endothelial cells, leukocytestumor cells, endothelial cells, leukocytestight junctions, leukocyte trafficking[35]
JAM2JAM3tumor cells, endothelial cells, leukocytestumor cells, endothelial cells, leukocytestight junctions, leukocyte trafficking[37]
JAM3JAM2tumor cells, endothelial cells, leukocytestumor cells, endothelial cells, leukocytestight junctions, leukocyte trafficking[37]
JAM3JAM3tumor cells, endothelial cells, leukocytestumor cells, endothelial cells, leukocytestight junctions, leukocyte trafficking[37]
PECAM1PECAM1endothelial cells, tumor cellsendothelial cells, tumor cellsangiogenesis, maintenance of endothelial barrier integrity[38]
THY1ITGAV_ITGB3endothelial cells, fibroblaststumor cellsadhesion and transmigration of tumor cells[39]
THY1ITGAX_ITGB2endothelial cells, fibroblastsimmune cellsleukocyte adhesion to activated endothelium[40]
THY1ITGAM_ITGB2endothelial cells, fibroblastsimmune cellsleukocyte adhesion to activated endothelium[40]
III. Triple-negative BC
ADGRE5CD55tumor cells, immune cellstumor cells, immune cellsmodulation of various tumorigenic mechanisms[41]
F11RF11Rtumor cells, endothelial cells, leukocytestumor cells, endothelial cells, leukocytestight junctions, EMT regulation, leukocyte trafficking[42]
F11RITGAL_ITGB2tumor cells, endothelial cells, leukocytesimmune cellsleukocyte transendothelial migration[36]
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