Exploration of Targeted Anti-tumor Therapy

Table 3. Characteristics and outcomes of TRT studies in NSCLC.

Study (first author, year)	Sample size	Therapeutic agent	Activity per cycle (GBq)	Number of cycles	Response criteria	Response	Median PFS (months)	Median OS (months)	Major toxicity
Rao, 2023 [34]	1	[¹⁷⁷Lu]Lu-FAP-2286	7	1	PERCIST	PR	Not reported	Not reported	None
Yang, 2024 [35]	1	[¹⁷⁷Lu]Lu-FAP-2286	7.4	1	PERCIST	PR	Not reported	Not reported	None
Liu, 2026 [28]	1	[¹⁷⁷Lu]Lu-FAPI-XT	11.1	1	RECIST 1.1	PD	0.75	Not reported	None
Fu, 2025 [29]	2	[¹⁷⁷Lu]Lu-LNC1004	3.33	Not specified	RECIST 1.1	Not reported	Not reported	Not reported	Not reported
Aggarwal, 2026 [33]	1	[¹⁷⁷Lu]Lu-PSMA-617	0.466 (single dose)	1	Not reported	Not reported	Not reported	Not reported	Not reported

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NSCLC: non-small cell lung cancer; OS: overall survival; PD: progressive disease; PERCIST: positron emission tomography Response Criteria in Solid Tumors; PFS: progression-free survival; PR: partial response; RECIST 1.1: Response Evaluation Criteria in Solid Tumors Version 1.1; TRT: targeted radioligand therapy.

Supplementary materials

The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1002368_sup_1.pdf.

Declarations

Author contributions

SM and SR: Conceptualization, Data curation, Formal analysis, Writing—original draft. KAR, MJAJ, and MA: Writing—review & editing, Visualization. AA, NA, and UAR: Data curation, Formal analysis. AAI: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable. This systematic review synthesizes data from previously published studies and does not involve human participants or animal subjects.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

All data generated or analyzed during this study are included in the manuscript.

Funding

Not applicable.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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