Exploration of Targeted Anti-tumor Therapy

Table 2. Characteristics and outcomes of PRRT studies in SCLC.

Study (first author, year)	Sample size	Therapeutic agent(s)	Activity per cycle (GBq)	Number of cycles	Response criteria	Response rate (PR+SD)	Median PFS (months)	Median OS (months)	Major toxicity
Serfling, 2023 [30]	28	Not specified PRRT	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported	Not reported
Lapa, 2016 [31]	4	[¹⁷⁷Lu]Lu-DOTATATE/TOC	7.6 ± 0.3	1–6	Not reported	50% (1 PR,1 SD)	11.9 (responders)	16 (responders)	None
Sollini, 2013 [26]	11	[⁹⁰Y]Y/[¹⁷⁷Lu]Lu-DOTATOC/TATE	2.6 (Y), 6.0 (Lu)	1–3	RECIST 1.1	0% (all PD)	NA	NA	G2-3 hematologic
Şen, 2023 [32]	14	[¹⁷⁷Lu]Lu-DOTATATE/TOC	7.5	1–6	RECIST 1.1	38.5% (PR+SD)	3.6	Not reported	None
Pless, 2004 [25]	6	[⁹⁰Y]Y-DOTATOC	2.22 (60 mCi/m²)	Median 2	WHO	0% (all PD)	1.3	3.6	G1-2 anemia
van Essen, 2006 [37]	3	[¹⁷⁷Lu]Lu-DOTA-Tyr3-Octreotate	7.4	1–2	SWOG	0% (all PD)	NA	NA	Liver enzyme elevation
Tuncel, 2025 [36]	1	[²²⁵Ac]Ac-DOTATATE	0.009 (9 MBq)	1	Not reported	100% (1 PR)	Not reported	Not reported	Not reported

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NA: not applicable; OS: overall survival; PD: progressive disease; PFS: progression-free survival; PR: partial response; PRRT: peptide receptor radionuclide therapy; RECIST 1.1: Response Evaluation Criteria in Solid Tumors Version 1.1; SCLC: small cell lung cancer; SD: stable disease; SWOG: Southwest Oncology Group; WHO: World Health Organization.

Supplementary materials

The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1002368_sup_1.pdf.

Declarations

Author contributions

SM and SR: Conceptualization, Data curation, Formal analysis, Writing—original draft. KAR, MJAJ, and MA: Writing—review & editing, Visualization. AA, NA, and UAR: Data curation, Formal analysis. AAI: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable. This systematic review synthesizes data from previously published studies and does not involve human participants or animal subjects.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

All data generated or analyzed during this study are included in the manuscript.

Funding

Not applicable.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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