From:  The evolving role of targeted radioligand therapy in small cell and non-small cell lung cancer: a systematic review

 Characteristics of included studies.

First author (year)CountryStudy designCancer typeSample size (treated)TargetDiagnostic agentTherapeutic agentTreatment setting
Pless, 2004 [25]SwitzerlandPilot trialSCLC27 (6)SSTR[111In]In-octreoscan[90Y]Y-DOTATOCSalvage
van Essen, 2006 [37]NetherlandsCase seriesSCLC3 (3)SSTR[111In]In-octreotide[177Lu]Lu-DOTA-Tyr3-octreotateSalvage
Yu, 2006 [27]ChinaPhase IIa trialSCLC and NSCLC43 (22)DNA/Histone[131I]Iodine-chTNT[131I]Iodine-chTNTPalliative
Sollini, 2013 [26]ItalyProspective trialSCLC24 (11)SSTR[68Ga]Ga-DOTATOC/TATE[90Y]Y/177Lu-DOTATOC/TATESalvage
Lapa, 2016 [31]GermanyRetrospective cohortSCLC21 (4)SSTR[68Ga]Ga-DOTATATE[177Lu]Lu-DOTATATE/TOCSalvage
Assadi, 2021 [24]IranProspective studyNot specified18 (1)FAP[177Lu]Lu-FAPI-46[177Lu]Lu-FAPI-46Palliative
Rao, 2023 [34]ChinaCase reportNSCLC1 (1)FAP[68Ga]Ga-FAP-2286[177Lu]Lu-FAP-2286Palliative
Şen, 2023 [32]GermanyRetrospective cohortSCLC67 (14)SSTR[68Ga]Ga-DOTATOC[177Lu]Lu-DOTATATE/TOCPalliative
Serfling, 2023 [30]GermanyRetrospective cohortSCLC100 (28)SSTR[68Ga]Ga-DOTATOCPRRT (Not Specified)Salvage
Yang, 2024 [35]ChinaCase reportNSCLC1 (1)FAP[68Ga]Ga-FAP-2286[177Lu]Lu-FAP-2286Palliative
Xie, 2024 [23]ChinaProspective cohortSCLC and NSCLC9 (9)FAP[68Ga]Ga-FAP-2286[177Lu]Lu-FAP-2286Palliative
Aggarwal, 2026 [33]IndiaCase reportNSCLC1 (1)PSMA[68Ga]Ga-PSMA-11[177Lu]Lu-PSMA-617Salvage
Liu, 2026 [28]ChinaPhase I trialNSCLC14 (1)FAP[68Ga]Ga-FAPI[177Lu]Lu-FAPI-XTSalvage
Fu, 2025 [29]ChinaPhase II trialNSCLC28 (2)FAP[68Ga]Ga-FAP-46[177Lu]Lu-LNC1004Salvage
Tuncel, 2025 [36]TurkeyCase reportSCLC1 (1)SSTR[18F]FDG and [68Ga]Ga-DOTATATE[225Ac]Ac-DOTATATESalvage

FAP: fibroblast activation protein; NSCLC: non-small cell lung cancer; PSMA: prostate-specific membrane antigen; SCLC: small cell lung cancer; SSTR: strong somatostatin receptor.