Exploration of Targeted Anti-tumor Therapy

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From: Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma

Table 4. Drug response-scores based on GEP

Score	Genes	Datasets	Reference
8-gene signature (dexamethasone/ thalidomide)	ATF2, CCND2, CFLAR, DDX17, HSPA1A, RIT1, RNF148, WHSC1	GSE16791	[169]
DM (DNMTi)	47 genes	E-MTAB-372 HMCLs	[200]
M³P (PIs and IMiDs)	47 genes in del17p	German MM study group (DSMM)	[177–179]
DRP (drug response prediction, melphalan and bortezomib)		GSE2658 (TT2/TT3a) GSE19784 (HOVON) GSE68871 (GIMEMAMMY-3006) GSE9782 (APEX)	[196]
IMiD-14	14 poor prognosis genes: XPO1, DDR2, TRAF3IP3, FAIM3 10 good prognosis genes: IL5RA, TNFRSF7, AMPD1, ENO2, ITGA6, FLJ22531, LAMA5, PGRMC2, SLC39A14, KIAA0247	GSE24080 GSE57317 GSE19784 (HOVON65/GMMG-HD4)	[201]
HA (HDACi)	37 genes	E-MTAB-372 GSE2658 E-TABM-937 and E-TABM-1088 (HMCLs)	[202]
DNMTi/HDACi (decitabine/quisinostat)	25/62 genes	E-MTAB-3178	[203]
VTD response (Bortezomib-Thalidomide-Dexamethasone)	5 genes: ACTR2, BAI2, ANK3, GALNT5, GLT1D1	GSE55145 GSE9872	[204]
DR (DNA repair, DNA damage agents)	17 bad prognostic 5 good prognostic	GSE24080 E-MTAB-372	[27]
EZ (EZH2 inhibitor)	15 genes	E-TABM-93 E-TABM-1088	[205]

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Declarations

Author contributions

SO performed data analyses and the writing of the paper. JM supervised the writing of the paper.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by grants from INCa (Institut National du Cancer) PLBIO18-362 PIT-MM and PLBIO19-098 INCA_13832FATidique, ANR (the French National Research Agency) under the “Investissements d’avenir” program with the reference ANR-16-IDEX-0006, ANR (TIE-Skip; 2017-CE15-0024-01), ANR-18-CE15-0010-01 PLASMADIFF-3D, SIRIC Montpellier Cancer (INCa_Inserm_DGOS_12553), Labex EpiGenMed and Institut Universitaire de France. The funders had no role in analysis, decision to publish, or preparation of the manuscript.

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