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From: Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma

Table 2. Datasets from MM patients used in genomics studies presented in this review

Dataset	Technique	Number of patients	GEO series accession number
HOVON-65/GMMG-HD4	Affymetrix HG U133 plus 2.0 platform	320	GSE19784
UAMS-TT2 UAMS-TT3	Affymetrix HG U133 plus 2.0 platform	340 214	GSE24080
MRC-IX	Affymetrix HG U133 plus 2.0 platform Gene Chip Mapping 500K Array set Genome variation profiling by SNP array SNP genotyping by SNP array	258 114	GSE15695
APEX/SUMMIT/CREST	Affymetrix U133 A/B platform	669	GSE9782
IFM-G	Affymetrix HG U133 plus 2.0 platform	182	GSE7039
Mayo Clinic cohort	Affymetrix U133A platform	162	GSE6477
CoMMpass	WES: Illumina TruSeq Exome Enrichment WES: Agilent SureSelect Human All Exon + untranslated regions (UTRs) Library RNA-Seq: Illumina truSeq Stranded mRNA	1,150	dbGaP phs000748.v7.p4
HM	Affymetrix HG U133 plus 2.0 platform	206	Array Express public database (E-MTAB-372)
GIMEMAMMY-3006		118	GSE68871

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GEO: Gene Expression Omnibus; HOVON65/GMMG-HD4: Dutch-Belgium Hemato-Oncology Group and German-speaking Myeloma Multicenter Group; UAMS-TT2/UAMS-TT3: University of Arkansas for Medical Sciences-Total Therapy 2/3; MRC-IX: Medical Research Council-IX; APEX: Assessment of Proteasome Inhibition for Extending Remissions; IFM-G: Intergroupe Francophone du Myelome; CoMMpass: the Relating Clinical Outcomes in MM to Personal Assessment of Genetic Profile Study; HM: Heidelberg-Montpellier; UTRs: untranslated regions

Declarations

Author contributions

SO performed data analyses and the writing of the paper. JM supervised the writing of the paper.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by grants from INCa (Institut National du Cancer) PLBIO18-362 PIT-MM and PLBIO19-098 INCA_13832FATidique, ANR (the French National Research Agency) under the “Investissements d’avenir” program with the reference ANR-16-IDEX-0006, ANR (TIE-Skip; 2017-CE15-0024-01), ANR-18-CE15-0010-01 PLASMADIFF-3D, SIRIC Montpellier Cancer (INCa_Inserm_DGOS_12553), Labex EpiGenMed and Institut Universitaire de France. The funders had no role in analysis, decision to publish, or preparation of the manuscript.

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