Exploration of Targeted Anti-tumor Therapy

Table 1. Transcriptomic characteristics in metastatic biopsies.

References	M1 location	Bulk transcriptomics	Concordance (primary and M1)
Laoukili et al. [8] (n = 12)	Peritoneal*, &	CMS4 (100%)	92%
Lenos et al. [9] (n = 52)	Peritoneal**, &	CMS1 (6%), CMS2 (8%), CMS3 (2%), CMS4 (85%)	63%
Piskol et al. [10] (n = 130)	Not defined&	CMS1 (17%), CMS2 (48%), CMS3 (8%), CMS4 (27%)	60%
Kamal et al. [11] (n = 257)	Lung, liver*	M1 (86%) and CMS4 (85%); M2 (63%) and CMS2 (52%)	NE
Eide et al. [12] (n = 295)	Liver*, &	CMS1 (6%), CMS2 (35%), CMS3 (2%), CMS4 (35%)	33%
Chowdhury et al. [13] (n = 10,776)	Multiple sites	CMS1 (10–16%), CMS2 (37–45%), CMS3 (11–13%), CMS4 (27–39%)	NE
Pitroda et al. [14] (n = 134)	Liver**, &	Canonical (33%), immune (28%), stromal (39%)	NE
Katipally et al. [15] (n = 240)	Liver**, &	Canonical (50%), immune (19%), stromal (31%)	NE

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*: Sample obtained from untreated patients; **: sample obtained from pretreated patients; &: sample obtained from resected metastatic biopsies; n: number of patients included in each cohort; M1: transcriptomic subtype characterized by inflammatory and T-cell infiltration; M2: transcriptomic subtype enriched in MYC and E2F targets. CMS: consensus molecular subtypes; NE: not evaluated.

Declarations

Acknowledgments

Professional medical writing assistance was provided by Kevin Clayton.

Author contributions

MR: Writing—original draft, Writing—review & editing. MM: Supervision, Writing—original draft, Writing—review & editing. S Madurga: Supervision, Writing—review & editing. FEGV: Writing—original draft, Writing—review & editing. MAR: Writing—original draft, Writing—review & editing. S Marín: Supervision, Writing—review & editing. MC: Conceptualization, Supervision, Writing—review & editing. JM: Conceptualization, Supervision, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

Joan Maurel, who is the Editorial Board Member of Exploration of Targeted Anti-tumor Therapy, had no involvement in the decision-making or the review process of this manuscript. The other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Both figures were created de novo by the authors using BioRender.com and do not reproduce or adapt material from previously published sources.

Funding

Authors acknowledge the support of MICIU/AEI/10.13039/501100011033/-European Commission FEDER funds [PID2023--150539OB-I00]; CIBER-EHD [EHD20PI03 and CB17/04/00023]; AC24/00028; AGAUR [2021-SGR-00350], and ICREA Foundation (ICREA Academia award). ARISTOS has received funding from the European Union’s Horizon Europe research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101081334. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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