Exploration of Targeted Anti-tumor Therapy

Table 3. Linear regression analysis of the recurrence score as a continuous variable and classical pathological features in pre- and post-menopausal patients

Pre-menopausal patients				Post-menopausal patients
Variable	Coefficient	95% CI	P-value	Variable	Coefficient	95% CI	P-value
Histology				Histology
NST	-	-	-	NST	-	-	-
Lobular	0.26	–5.56 to 6.08	0.93	Lobular	–1.78	–5.87 to 2.31	0.39
Other	–4.61	–12.14 to 2.93	0.23	Other	0.03	–5.53 to 5.59	0.99
LVI	1.52	–2.94 to 5.97	0.50	LVI	–0.62	–4.23 to 2.99	0.73
PNI	–1.09	–5.52 to 3.33	0.62	PNI	–0.52	–4.01 to 2.97	0.77
Grading				Grading
1	-	-	-	1	-	-	-
2	1.11	–78.25 to 10.46	0.81	2	4.06	–1.95 to 10.10	0.184
3	6.08	–3.98 to 16.14	0.23	3	6.89	0.55 to 13.22	0.03
ER%	–0.41	–0.71 to 0.10	0.01	ER%	–0.24	–0.69 to 0.21	0.30
PgR%	–0.18	–0.24 to –0.12	< 0.0001	PgR%	–0.14	–0.18 to –0.09	< 0.0001
HER2				HER2
0	-	-	-	0	-	-	-
1–2	–1.66	–5.93 to 2.54	0.43	1–2	2.59	–0.63 to 5.82	0.11
Ki67%	0.26	0.05 to 0.47	0.02	Ki67%	0.28	0.13 to 0.44	0.001

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Bold indicates statistically significant P-values (≤ 0.05). CI: confidence interval; NST: non-special type; LVI: lymphovascular invasion; PNI: perineural invasion; ER: estrogen receptor; PgR: progesterone receptor; HER2: human epidermal growth factor-receptor 2

Declarations

Author contributions

FM: Conceptualization, Formal analysis, Writing—original draft, Supervision. SN: Conceptualization, Writing—original draft. G Motta: Conceptualization, Data curation, Writing—review & editing, Supervision. MVS: Resources. C Carnaghi: Resources. MP: Data curation. CG: Data curation. G Corsaro: Data curation. C Conti: Writing—review & editing. LM: Writing—review & editing. GP: Writing—review & editing. SM: Investigation, Resources. GMV: Investigation, Resources. G Magro: Investigation, Resources. G Catanuto: Resources, Writing—review & editing. G Castiglione: Resources, Writing—review & editing. FC: Resources, Writing—review & editing. AR: Investigation, Resources. MC: Conceptualization, Resources. PV: Conceptualization, Resources, Supervision, Writing—review & editing. All the authors read and approved the final version of the manuscript.

Conflicts of interest

Antonio Rizzo and Stefano Marletta who are the Guest Editors of Exploration of Targeted Anti-tumor Therapy had no involvement in the decision-making or the review process of this manuscript. The other authors declare that they have no conflicts of interest related to the present work.

Ethical approval

The study was conducted in accordance with the 2013 Declaration of Helsinki and Good Clinical Practice. No ethics approval is required for this study as this is a retrospective collection of data from a standard database for quality assurance assessment and not an observational study.

Consent to participate

Informed consent was obtained from all individual participants included in the study. Patients consent to sharing data belonging to this database upon admission. Patients also signed written informed consent before Oncotype DX testing.

Consent to publication

Not applicable.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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