Table Info

Table 4.

Clinical trials on ICIs in gynecological malignancies

Disease	Setting	ICIs
		CTLA-4	PD-1	PD-L1
		Ipilimumab Tremelimumab	Pembrolizumab Nivolumab Dostarlimab Cemiplimab	Ave Atezolizumab Durvalumab
OC	NACT first-line		ENGOT OV 43 [60] FIRST [61] ATHENA [62] MITO 28 [63]	AGO DUO [59]
	ROC Plat Se	NRG-GY003 [53]	NCT02873962 [77]	ANITA [79] ATALANTE [80]
	ROC Plat R		NCT02440425 [52] NCT02873962 [74]	EORTC 1508 [81] NCT02484404 [82]
EC	Advanced (III-IV) recurrent CT naive		LEAP-001 [41] NRG-GY018 [45]	MITO END-3 [44] ATTEND [42] RUBY [43]
EC	Recurrent prior CT	NCT03015129 [37] NCT02982486 [40] NCT02834013 [73]	NCT02899793 [38] KEYNOTE-775 [46] NCT02549209 [45]	MITO END-3 [44] ATTEND [42] NCT02912572 [39] NCT03526432 [83]
CC	LACC	NCT01711515 [74]	MITO CERV 3 [15] NCT04221945 [14]
CC	Recurrent metastatic		NRG-GY002 [75] KEYNOTE-826 [16] REGENERON [19] CX 8 [76]	NCT02921269 [78] BEAT [17]

NACT: neoadiuvant chemotherapy; ROC: recurrent epithelial ovarian cancer; Plat Se/Plat R: platinum sensitive/resistant; LACC: locally advanced cervical cancer

Declarations

Author contributions

DL contributed to conception and design of the study; VC wrote the first draft of the manuscript; GD, AP, VS, MM, CN, FC, GS wrote sections of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

VC, MM, CN, FC declare that they have no conflicts of interest. Outside the submitted work:

DL has served on advisory boards for Clovis Oncology, AstraZeneca, Genmab/Seattle Genetics, MSD, ImmunoGen, PharmaMar, Roche, and Tesaro/GSK, received support for travel or accommodation from AstraZeneca, GSK and Roche and institutional research funding from Merck, GSK, Clovis, Pharmamar.

GD has served on advisory board of Beigene and received support for travel and accomodation from Roche.

VS has served on advisory board of Roche, Astra Zeneca, MSD, GSK and Clovis and received support for travel and accomodation from Pharmamar, GSK, Roche.

AP worked at Astra Zeneca Medical Affair Division until Dec 2018.

GS has served on advisory boards for TESARO Bio Italy S.r.l, Johnson & Johnson, Clovis Oncology Italy S.r.l. He received support for travel or accommodation from MSD Italy S.r.l and Clovis Oncology Italy S.r.l, and institutional research funding from MSD Italy S.r.l.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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