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Table 1

From: Future perspectives: targeting fibroblast growth factor receptor 1 to enhance the efficacy of immunotherapy

Table 1. Prevalence of FGFR1 abnormalities in various tumor types

Tumor type	Amplifications (%)	Mutations (%)	Gene rearrangements (%)	Overexpression (%)
Lung cancer (squamous cell carcinoma)	10–56.8	N546K, K656E, V561M (varied)	FGFR1-TACC1 (not quantified)	4.4–13
Breast cancer	7–15	S125L, K566R (0.19)	NR	6.1–58
Glioma/glioblastoma	2–66.7	N546K, K656E (3–21)	FGFR1-TACC1 (2–4)	Rare
Prostate cancer	NR	NR	NR	20–40
Head and neck tumors	6–17	NR	NR	10.6–82
Renal cell carcinoma	NR	NR	NR	98 (primary), 82.5 (metastatic)
Myeloproliferative disorders	NR	NR	BCR-FGFR1, FGFR1OP-RET, FGFR1OP-FGFR1 (common)	Rare

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NR: not reported; FGFR1: fibroblast growth factor receptor 1

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IT: Formal analysis, Writing—original draft, Writing—review & editing.

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