Table Info

Table 1.

Characteristics of OC patients (n = 156)

Characteristics	BRCA1 (n = 48)	BRCA2 (n = 15)	*WT (n =* 93)**
Mean age (age range)	52.9 (36–70)	60.5 (43–76)	59.5 (28–83)
FIGO stage
IIIC	21 (44%)	9 (60%)	46 (49%)
IVA	1 (2%)	1 (7%)	3 (3%)
IVB	26 (54%)	5 (33%)	44 (47%)
NACT regimen
MP (mitomycin 10 mg/m² + cisplatin 100 mg/m², every 28 days)	26 (54%)	2 (13%)	-
TCbP (paclitaxel 175 mg/m² + carboplatin AUC 6)	22 (46%)	13 (87%)	93 (100%)
RECIST 1.1
Complete response	3 (6%)	1 (7%)	0 (0)
Partial response	33 (69%)	12 (80%)	62 (67%)
Stable disease	11 (23%)	1 (7%)	24 (26%)
Progressive disease	1 (2%)	1 (7%)	7 (8%)
CRS (omentum)
CRS1	10 (21%)	1 (7%)	28 (30%)
CRS2	23 (48%)	2 (13%)	47 (51%)
CRS3, near-complete response	5 (10%)	1 (7%)	9 (10%)
CRS3, complete response	7 (15%)	8 (53%)	0 (0)
No debulking surgery/no omentectomy^※	3 (6%)	3 (20%)	9 (10%)

^※In the BRCA1/2-mutated subjects, four women (three BRCA2 carriers and one BRCA1 carrier) had an unresectable tumor after 3–4 cycles of NACT, one patient had a partial clinical response but was considered at high risk of post-operative complications due to comorbidities and continued on immunotherapy and olaparib, and one patient died during NACT due to pneumonia. In the WT group, all cases without debulking surgery were related to insufficient clinical response. AUC: area under the curve; CRS: chemotherapy response score; FIGO: International Federation of Gynecology and Obstetrics; MP: mitomycin and cisplatin; NACT: neoadjuvant chemotherapy; OC: ovarian cancer; RECIST: Response Evaluation Criteria In Solid Tumors; TCbP: carboplatin and paclitaxel; WT: wild-type

Supplementary materials

The supplementary Tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1002325_sup_1.xlsx.

Declarations

Acknowledgments

We are cordially thankful to Dr. Priscilla Amankwah for her invaluable help in improving this manuscript.

Author contributions

AS: Conceptualization, Investigation, Formal analysis, Writing—review & editing. TG: Conceptualization, Investigation, Resources. DE: Data curation, Resources. AS, AI, and AN: Investigation. IB, PK, and AB: Resources, Supervision. EI: Conceptualization, Writing—original draft, Funding acquisition. All authors read and approved the submitted version.

Conflicts of interest

Evgeny Imyanitov who is the Editorial Board Member of Exploration of Targeted Anti-tumor Therapy had no involvement in the decision-making or the review process of this manuscript. The other authors declare no conflicts of interest.

Ethical approval

The study was approved by the Institutional Review Board of the N.N. Petrov Institute of Oncology (protocol No.1, 23.01.2020).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

All datasets for this study are included in the manuscript and the supplementary files.

Funding

This study is supported by the Russian Science Foundation, grant number [21-75-30015]. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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