ZM: Writing—original draft, Writing—review & editing, Visualization. KS and AT: Writing—original draft, Writing—review & editing. ZA and DT: Writing—original draft, Writing—review & editing, Funding acquisition. AB: Conceptualization, Writing—original draft, Writing—review & editing, Visualization, Supervision. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This research has been funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant No. AP22783767), and by Nazarbayev University under Faculty Development grant, code: 20122022FD4134 (Project M2O-DISK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
References
Fabisiewicz A, Grzybowska E. CTC clusters in cancer progression and metastasis.Med Oncol. 2017;34:12. [DOI] [PubMed]
Lin D, Shen L, Luo M, Zhang K, Li J, Yang Q, et al. Circulating tumor cells: biology and clinical significance.Signal Transduct Target Ther. 2021;6:404. [DOI] [PubMed] [PMC]
Zhang Y, Zhao Y, Cole T, Zheng J, Bayinqiaoge, Guo J, et al. Microfluidic flow cytometry for blood-based biomarker analysis.Analyst. 2022;147:2895–917. [DOI] [PubMed]
Ma L, Guo H, Zhao Y, Liu Z, Wang C, Bu J, et al. Liquid biopsy in cancer current: status, challenges and future prospects.Signal Transduct Target Ther. 2024;9:336. [DOI] [PubMed] [PMC]
de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, et al. Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer.Clin Cancer Res. 2008;14:6302–9. [DOI] [PubMed]
Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer.N Engl J Med. 2004;351:781–91. [DOI] [PubMed]
Cohen SJ, Punt CJA, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, et al. Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer.J Clin Oncol. 2008;26:3213–21. [DOI] [PubMed]
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, et al. EMT and Dissemination Precede Pancreatic Tumor Formation.Cell. 2012;148:349–61. [DOI] [PubMed] [PMC]
Jiang L, Yang H, Cheng W, Ni Z, Xiang N. Droplet microfluidics for CTC-based liquid biopsy: a review.Analyst. 2023;148:203–21. [DOI] [PubMed]
Alix-Panabières C, Pantel K. Circulating Tumor Cells: Liquid Biopsy of Cancer.Clin Chem. 2013;59:110–8. [DOI] [PubMed]
Mostert B, Sleijfer S, Foekens JA, Gratama JW. Circulating tumor cells (CTCs): Detection methods and their clinical relevance in breast cancer.Cancer Treat Rev. 2009;35:463–74. [DOI] [PubMed]
Costa C, Abal M, López-López R, Muinelo-Romay L. Biosensors for the Detection of Circulating Tumour Cells.Sensors (Basel). 2014;14:4856–75. [DOI] [PubMed] [PMC]
Alawajji RA, Alsudani ZAN, Biris AS, Kannarpady GK. Biosensor Design for the Detection of Circulating Tumor Cells Using the Quartz Crystal Resonator Technique.Biosensors (Basel). 2023;13:433. [DOI] [PubMed] [PMC]
Paglia EB, Baldin EKK, Freitas GP, Santiago TSA, Neto JBMR, Silva JVL, et al. Circulating Tumor Cells Adhesion: Application in Biosensors.Biosensors (Basel). 2023;13:882. [DOI] [PubMed] [PMC]
Xu T, Zhou J, Li X, Ke W, Liu J, Gao H, et al. Electrochemical sensing technology for liquid biopsy of circulating tumor cells-a review.Bioelectrochemistry. 2021;140:107823. [DOI] [PubMed]
Safarpour H, Dehghani S, Nosrati R, Zebardast N, Alibolandi M, Mokhtarzadeh A, et al. Optical and electrochemical-based nano-aptasensing approaches for the detection of circulating tumor cells (CTCs).Biosens Bioelectron. 2020;148:111833. [DOI] [PubMed]
Vajhadin F, Mazloum-Ardakani M, Sanati A, Haghniaz R, Travas-Sejdic J. Optical cytosensors for the detection of circulating tumour cells.J Mater Chem B. 2022;10:990–1004. [DOI] [PubMed]
Cho HY, Choi JH, Lim J, Lee SN, Choi JW. Microfluidic Chip-Based Cancer Diagnosis and Prediction of Relapse by Detecting Circulating Tumor Cells and Circulating Cancer Stem Cells.Cancers (Basel). 2021;13:1385. [DOI] [PubMed] [PMC]
Hao HC, Yao DJ. Detection of Cancer Cells on a Chip.Curr Top Med Chem. 2015;15:1543–50. [DOI] [PubMed]
Hassan EM, Willmore WG, DeRosa MC. Aptamers: Promising Tools for the Detection of Circulating Tumor Cells.Nucleic Acid Ther. 2016;26:335–47. [DOI] [PubMed]
Hussain SH, Huertas CS, Mitchell A, Deman AL, Laurenceau E. Biosensors for circulating tumor cells (CTCs)-biomarker detection in lung and prostate cancer: Trends and prospects.Biosens Bioelectron. 2022;197:113770. [DOI] [PubMed]
Vermesh O, Aalipour A, Ge TJ, Saenz Y, Guo Y, Alam IS, et al. An intravascular magnetic wire for the high-throughput retrieval of circulating tumour cells in vivo.Nat Biomed Eng. 2018;2:696–705. [DOI] [PubMed] [PMC]
Lux A, Bott H, Malek NP, Zengerle R, Maucher T, Hoffmann J. Real-Time Detection of Tumor Cells during Capture on a Filter Element Significantly Enhancing Detection Rate.Biosensors (Basel). 2021;11:312. [DOI] [PubMed] [PMC]
Chen X, Xu P, Lin W, Jiang J, Qu H, Hu X, et al. Label-free detection of breast cancer cells using a functionalized tilted fiber grating.Biomed Opt Express. 2022;13:2117–29. [DOI] [PubMed] [PMC]
Shen H, Liu L, Yuan Z, Liu Q, Li B, Zhang M, et al. Novel cytosensor for accurate detection of circulating tumor cells based on a dual-recognition strategy and BSA@Ag@Ir metallic-organic nanoclusters.Biosens Bioelectron. 2021;179:113102. [DOI] [PubMed]
Mendelaar PAJ, Kraan J, Van M, Zeune LL, Terstappen LWMM, Oomen-de Hoop E, et al. Defining the dimensions of circulating tumor cells in a large series of breast, prostate, colon, and bladder cancer patients.Mol Oncol. 2021;15:116–25. [DOI] [PubMed] [PMC]
Huang G, Li F, Zhao X, Ma Y, Li Y, Lin M, et al. Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chem Rev. 2017;117:12764–850. [DOI] [PubMed] [PMC]
Andree KC, van Dalum G, Terstappen LWMM. Challenges in circulating tumor cell detection by the CellSearch system.Mol Oncol. 2016;10:395–407. [DOI] [PubMed] [PMC]
Jiang W, Han L, Yang L, Xu T, He J, Peng R, et al. Natural Fish Trap-Like Nanocage for Label-Free Capture of Circulating Tumor Cells.Adv Sci (Weinh). 2020;7:2002259. [DOI] [PubMed] [PMC]
Kapeleris J, Müller Bark J, Ranjit S, Irwin D, Hartel G, Warkiani ME, et al. Prognostic value of integrating circulating tumour cells and cell-free DNA in non-small cell lung cancer.Heliyon. 2022;8:e09971. [DOI] [PubMed] [PMC]
Niitsu K, Nakanishi T, Murakami S, Matsunaga M, Kobayashi A, Karim NM, et al. A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome.IEEE Trans Biomed Circuits Syst. 2019;13:470–9. [DOI] [PubMed]
Akpe V, Kim TH, Brown CL, Cock IE. Circulating tumour cells: a broad perspective.J R Soc Interface. 2020;17:20200065. [DOI]
Allan AL, Keeney M. Circulating Tumor Cell Analysis: Technical and Statistical Considerations for Application to the Clinic.J Oncol. 2010;2010:426218. [DOI] [PubMed] [PMC]
Pang Y, Wang C, Xiao R, Sun Z. Dual-Selective and Dual-Enhanced SERS Nanoprobes Strategy for Circulating Hepatocellular Carcinoma Cells Detection.Chemistry. 2018;24:7060–7. [DOI] [PubMed]
Regmi S, Fu A, Luo KQ. High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System.Sci Rep. 2017;7:39975. [DOI] [PubMed] [PMC]
Brungs D, Lynch D, Luk AW, Minaei E, Ranson M, Aghmesheh M, et al. Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer.World J Gastroenterol. 2018;24:810–8. [DOI] [PubMed] [PMC]
Zhou J, Tu C, Liang Y, Huang B, Fang Y, Liang X, et al. The label-free separation and culture of tumor cells in a microfluidic biochip.Analyst. 2020;145:1706–15. [DOI] [PubMed]
Ramos-Medina R, López-Tarruella S, Del Monte-Millán M, Massarrah T, Martín M. Technical Challenges for CTC Implementation in Breast Cancer.Cancers (Basel). 2021;13:4619. [DOI] [PubMed] [PMC]
Mizutani T, Kondo T, Darmanin S, Tsuda M, Tanaka S, Tobiume M, et al. A Novel FRET-Based Biosensor for the Measurement of BCR-ABL Activity and Its Response to Drugs in Living Cells.Clin Cancer Res. 2010;16:3964–75. [DOI] [PubMed]
Nowrin K, Sohal SS, Peterson G, Patel R, Walters EH. Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer.Expert Rev Respir Med. 2014;8:547–59. [DOI] [PubMed]
Schölch S, García SA, Iwata N, Niemietz T, Betzler AM, Nanduri LK, et al. Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer.Oncotarget. 2016;7:27232–42. [DOI] [PubMed] [PMC]
Schuster E, Taftaf R, Reduzzi C, Albert MK, Romero-Calvo I, Liu H. Better together: circulating tumor cell clustering in metastatic cancer.Trends Cancer. 2021;7:1020–32. [DOI] [PubMed] [PMC]
Heeke S, Mograbi B, Alix-Panabières C, Hofman P. Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment.Cells. 2019;8:714. [DOI] [PubMed] [PMC]
Li X, Zheng J, Zhu J, Huang X, Zhu H, Chen B. Circulating tumor cells: Biological features and survival mechanisms.Biocell. 2023;47:1771–81. [DOI]
Ried K, Eng P, Sali A. Screening for Circulating Tumour Cells Allows Early Detection of Cancer and Monitoring of Treatment Effectiveness: An Observational Study.Asian Pac J Cancer Prev. 2017;18:2275–85. [DOI] [PubMed] [PMC]
Bobek V, Gurlich R, Eliasova P, Kolostova K. Circulating tumor cells in pancreatic cancer patients: Enrichment and cultivation.World J Gastroenterol. 2014;20:17163–70. [DOI] [PubMed] [PMC]
Edd JF, Mishra A, Smith KC, Kapur R, Maheswaran S, Haber DA, et al. Isolation of circulating tumor cells.iScience. 2022;25:104696. [DOI] [PubMed] [PMC]
Abusamra SM, Barber R, Sharafeldin M, Edwards CM, Davis JJ. The integrated on-chip isolation and detection of circulating tumour cells.Sens Diagn. 2024;3:562–84. [DOI] [PubMed] [PMC]
Burinaru TA, Adiaconiţă B, Avram M, Preda P, Enciu A-M, Chiriac E, et al. Electrochemical impedance spectroscopy based microfluidic biosensor for the detection of circulating tumor cells.Mater Today Commun. 2022;32:104016. [DOI]
Chen H, Zhang Z, Liu H, Zhang Z, Lin C, Wang B. Hybrid magnetic and deformability based isolation of circulating tumor cells using microfluidics.AIP Adv. 2019;9:025023. [DOI]
Wang J. Electrochemical biosensors: Towards point-of-care cancer diagnostics.Biosens Bioelectron. 2006;21:1887–92. [DOI] [PubMed]
Gu Y, Ju C, Li Y, Shang Z, Wu Y, Jia Y, et al. Detection of circulating tumor cells in prostate cancer based on carboxylated graphene oxide modified light addressable potentiometric sensor.Biosens Bioelectron. 2015;66:24–31. [DOI] [PubMed]
Peng Y, Lu B, Deng Y, Yang N, Li G. A dual-recognition-controlled electrochemical biosensor for accurate and sensitive detection of specific circulating tumor cells.Biosens Bioelectron. 2022;201:113973. [DOI] [PubMed]
Khaksari S, Ameri AR, Taghdisi SM, Sabet M, Bami SMJG, Abnous K, et al. A microfluidic electrochemical aptasensor for highly sensitive and selective detection of A549 cells as integrin α6β4-containing cell model via IDA aptamers.Talanta. 2023;252:123781. [DOI] [PubMed]
Hsiao YS, Ho BC, Yan HX, Kuo CW, Chueh DY, Yu HH, et al. Integrated 3D conducting polymer-based bioelectronics for capture and release of circulating tumor cells.J Mater Chem B. 2015;3:5103–10. [DOI] [PubMed]
Han R, Li Y, Chen M, Li W, Ding C, Luo X. Antifouling Electrochemical Biosensor Based on the Designed Functional Peptide and the Electrodeposited Conducting Polymer for CTC Analysis in Human Blood.Anal Chem. 2022;94:2204–11. [DOI] [PubMed]
Chen Y, Peng J, Lai Y, Wu B, Sun L, Weng J. Ultrasensitive label-free detection of circulating tumor cells using conductivity matching of two-dimensional semiconductor with cancer cell.Biosens Bioelectron. 2019;142:111520. [DOI] [PubMed]
Kun Q, Lin Y, Peng H, Cheng L, Cui HF, Hong N, et al. A “signal-on” switch electrochemiluminescence biosensor for the detection of tumor cells.J Electroanal Chem. 2018;808:101–6. [DOI]
Zhou H, You L, Zhang J, Hao T, Gao W, Xie J, et al. FSCV/ECL dual-mode detection of circulating tumor cells based on multi-functionalized 2D bionanomaterials.Sensor Actuat B-Chem. 2023;390:134013. [DOI]
Li X, Zhang P, Dou L, Wang Y, Sun K, Zhang X, et al. Detection of Circulating Tumor Cells in Breast Cancer Patients by Nanopore Sensing with Aptamer-Mediated Amplification.ACS Sens. 2020;5:2359–66. [DOI] [PubMed]
Chiavaioli F, Gouveia CAJ, Jorge PAS, Baldini F. Towards a Uniform Metrological Assessment of Grating-Based Optical Fiber Sensors: From Refractometers to Biosensors.Biosensors (Basel). 2017;7:23. [DOI] [PubMed] [PMC]
Valagiannopoulos C, Tosi D. Scattering integral equation formulation for intravascular inclusion biosensing.Sci Rep. 2024;14:14978. [DOI] [PubMed] [PMC]
Loyez M, Hassan EM, Lobry M, Liu F, Caucheteur C, Wattiez R, et al. Rapid Detection of Circulating Breast Cancer Cells Using a Multiresonant Optical Fiber Aptasensor with Plasmonic Amplification.ACS Sens. 2020;5:454–63. [DOI] [PubMed]
Nurlankyzy M, Kantoreyeva K, Myrkhiyeva Z, Ashikbayeva Z, Baiken Y, Kanayeva D, et al. Label-free optical fiber biosensor for the detection of CD44-expressing breast cancer cells.Sens Bio-Sens Res. 2024;44:100661. [DOI]
Chang TK, Tung PC, Lee MJ, Lee W. A liquid-crystal aptasensing platform for label-free detection of a single circulating tumor cell.Biosens Bioelectron. 2022;216:114607. [DOI] [PubMed]
Sanati A, Esmaeili Y, Khavani M, Bidram E, Rahimi A, Dabiri A, et al. Smartphone-assisted lab-in-a-tube device using gold nanocluster-based aptasensor for detection of MUC1-overexpressed tumor cells.Anal Chim Acta. 2023;1252:341017. [DOI] [PubMed]
Alix-Panabières C, Pantel K. Challenges in circulating tumour cell research.Nat Rev Cancer. 2014;14:623–31. [DOI] [PubMed]
Shen Z, Wu A, Chen X. Current detection technologies for circulating tumor cells.Chem Soc Rev. 2017;46:2038–56. [DOI] [PubMed] [PMC]
Deng G, Herrler M, Burgess D, Manna E, Krag D, Burke JF. Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients.Breast Cancer Res. 2008;10:R69. [DOI] [PubMed] [PMC]
Fabisiewicz A, Szostakowska-Rodzos M, Zaczek AJ, Grzybowska EA. Circulating Tumor Cells in Early and Advanced Breast Cancer; Biology and Prognostic Value.Int J Mol Sci. 2020;21:1671. [DOI] [PubMed] [PMC]
Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology.Nature. 2007;450:1235–9. [DOI] [PubMed] [PMC]
Pedrol E, Garcia-Algar M, Massons J, Nazarenus M, Guerrini L, Martínez J, et al. Optofluidic device for the quantification of circulating tumor cells in breast cancer.Sci Rep. 2017;7:3677. [DOI] [PubMed] [PMC]
Han L, Wan Q, Zheng A, Guo Y, Chen Y. Demonstration of a Flexible Graphene-Based Biosensor for Sensitive and Rapid Detection of Ovarian Cancer Cells.Nanoscale Res Lett. 2021;16:181. [DOI] [PubMed] [PMC]
Wan Q, Han L, Guo Y, Yu H, Tan L, Zheng A, et al. Graphene-Based Biosensors with High Sensitivity for Detection of Ovarian Cancer Cells.Molecules. 2021;26:7265. [DOI] [PubMed] [PMC]
Cetin D, Okan M, Bat E, Kulah H. A comparative study on EpCAM antibody immobilization on gold surfaces and microfluidic channels for the detection of circulating tumor cells.Colloids Surf B Biointerfaces. 2020;188:110808. [DOI] [PubMed]
Wang Z, Wu Z, Ding P, Sun N, Feng S, Xing C, et al. Selective capture of circulating tumor cells by antifouling nanostructure substrate made of hydrogel nanoparticles.Colloids Surf B Biointerfaces. 2021;202:111669. [DOI] [PubMed]
Wang Z, Wu Z, Sun N, Cao Y, Cai X, Yuan F, et al. Antifouling hydrogel-coated magnetic nanoparticles for selective isolation and recovery of circulating tumor cells.J Mater Chem B. 2021;9:677–82. [DOI] [PubMed]
Xiang Y, Zhang H, Lu H, Wei B, Su C, Qin X, et al. Bioorthogonal Microbubbles with Antifouling Nanofilm for Instant and Suspended Enrichment of Circulating Tumor Cells.ACS Nano. 2023;17:9633–46. [DOI] [PubMed]
Wang X, Wang L, Lin H, Zhu Y, Huang D, Lai M, et al. Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy.Front Oncol. 2024;14:1303335. [DOI] [PubMed] [PMC]
Zhang S, Li L, Wang T, Bian L, Hu H, Xu C, et al. Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients.BMC Cancer. 2016;16:526. [DOI] [PubMed] [PMC]
Thawany P, Poonam, Singhal NK, Tiwari UK, Deep A. Detection of circulating tumor cells using D-optical fiber SPR sensor.Appl Nanosci. 2023;13:5459–65. [DOI]
Weng WH, Ho IL, Pang CC, Pang SN, Pan TM, Leung WH. Real-time circulating tumor cells detection via highly sensitive needle-like cytosensor-demonstrated by a blood flow simulation.Biosens Bioelectron. 2018;116:51–9. [DOI] [PubMed]
Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, et al. Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer.J Clin Oncol. 2005;23:1420–30. [DOI] [PubMed]
Man Y, Wang Q, Kemmner W. Currently Used Markers for CTC Isolation—Advantages, Limitations and Impact on Cancer Prognosis.Clinic Experiment Pathol. 2011;1:1000102. [DOI]
Li Y, Wu G, Yang W, Wang X, Duan L, Niu L, et al. Prognostic value of circulating tumor cells detected with the CellSearch system in esophageal cancer patients: a systematic review and meta-analysis.BMC Cancer. 2020;20:581. [DOI] [PubMed] [PMC]
Yang C, Zou K, Yuan Z, Guo T, Xiong B. Prognostic value of circulating tumor cells detected with the CellSearch System in patients with gastric cancer: evidence from a meta-analysis.Onco Targets Ther. 2018;11:1013–23. [DOI] [PubMed] [PMC]
Jin T, Liang PP, Chen ZH, He FJ, Li ZD, Chen ZW, et al. Association between circulating tumor cells in the peripheral blood and the prognosis of gastric cancer patients: a meta-analysis.Ther Adv Med Oncol. 2023;15:17588359231183678. [DOI] [PubMed] [PMC]
Gorges TM, Stein A, Quidde J, Hauch S, Röck K, Riethdorf S, et al. Improved Detection of Circulating Tumor Cells in Metastatic Colorectal Cancer by the Combination of the CellSearch® System and the AdnaTest®.PLoS One. 2016;11:e0155126. [DOI] [PubMed] [PMC]
Hille C, Gorges TM, Riethdorf S, Mazel M, Steuber T, Amsberg GV, et al. Detection of Androgen Receptor Variant 7 (ARV7) mRNA Levels in EpCAM-Enriched CTC Fractions for Monitoring Response to Androgen Targeting Therapies in Prostate Cancer.Cells. 2019;8:1067. [DOI] [PubMed] [PMC]
Saucedo-Zeni N, Mewes S, Niestroj R, Gasiorowski L, Murawa D, Nowaczyk P, et al. A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire.Int J Oncol. 2012;41:1241–50. [DOI] [PubMed] [PMC]
Zhang H, Gong S, Liu Y, Liang L, He S, Zhang Q, et al. Enumeration and molecular characterization of circulating tumor cell using an in vivo capture system in squamous cell carcinoma of head and neck.Chin J Cancer Res. 2017;29:196–203. [DOI] [PubMed] [PMC]
Gallerani G, Cocchi C, Bocchini M, Piccinini F, Fabbri F. Characterization of Tumor Cells Using a Medical Wire for Capturing Circulating Tumor Cells: A 3D Approach Based on Immunofluorescence and DNA FISH.J Vis Exp. 2017;130:56936. [DOI] [PubMed] [PMC]
Nowaczyk P, Dlugaszewska B, Herold S, Krahn T, Mayer M, Morgenthaler NG, et al. A novel technology for in vivo isolation of circulating tumor cells in breast cancer patients. 2014. pp. 59.
Gorges TM, Penkalla N, Schalk T, Joosse SA, Riethdorf S, Tucholski J, et al. Enumeration and Molecular Characterization of Tumor Cells in Lung Cancer Patients Using a Novel In Vivo Device for Capturing Circulating Tumor Cells.Clin Cancer Res. 2016;22:2197–206. [DOI] [PubMed]
Miller MC, Robinson PS, Wagner C, O’Shannessy DJ. The Parsortix™ Cell Separation System—A versatile liquid biopsy platform.Cytometry A. 2018;93:1234–9. [DOI] [PubMed] [PMC]
Smit DJ, Pantel K. Circulating tumor cells as liquid biopsy markers in cancer patients.Mol Aspects Med. 2024;96:101258. [DOI] [PubMed]
Di Cosimo S, Silvestri M, De Marco C, Calzoni A, De Santis MC, Carnevale MG, et al. Low-pass whole genome sequencing of circulating tumor cells to evaluate chromosomal instability in triple-negative breast cancer.Sci Rep. 2024;14:20479. [DOI] [PubMed] [PMC]
Ntzifa A, Marras T, Kallergi G, Kotsakis A, Georgoulias V, Lianidou E. Comprehensive liquid biopsy analysis for monitoring NSCLC patients under second-line osimertinib treatment.Front Oncol. 2024;14:1435537. [DOI] [PubMed] [PMC]
Welsch E, Bonstingl L, Holzer B, Schuster E, Weiß E, Zaharie A, et al. Multi-marker analysis of circulating tumor cells in localized intermediate/high-risk and metastatic prostate cancer.Clin Exp Metastasis. 2024;41:937–45. [DOI] [PubMed] [PMC]
Ciccioli M, Kim K, Khazan N, Khoury JD, Cooke MJ, Miller MC, et al. Identification of circulating tumor cells captured by the FDA-cleared Parsortix® PC1 system from the peripheral blood of metastatic breast cancer patients using immunofluorescence and cytopathological evaluations.J Exp Clin Cancer Res. 2024;43:240. [DOI] [PubMed] [PMC]
M Saini V, Oner E, Ward MP, Hurley S, Henderson BD, Lewis F, et al. A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer.Mol Oncol. 2024. [DOI] [PubMed]
Dizdar L, Fluegen G, van Dalum G, Honisch E, Neves RP, Niederacher D, et al. Detection of circulating tumor cells in colorectal cancer patients using the GILUPI CellCollector: results from a prospective, single‐center study.Mol Oncol. 2019;13:1548–58. [DOI] [PubMed] [PMC]
Theil G, Fischer K, Weber E, Medek R, Hoda R, Lücke K, et al. The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes—A Proof-of-Concept Study.PLoS One. 2016;11:e0158354. [DOI] [PubMed] [PMC]
Theil G, Boehm C, Fischer K, Bialek J, Hoda R, Weber E, et al. In vivo isolation of circulating tumor cells in patients with different stages of prostate cancer.Oncol Lett. 2021;21:357. [DOI] [PubMed] [PMC]
Theil G, Lindner C, Bialek J, Fornara P. Association of Circulating Tumor Cells with Inflammatory and Biomarkers in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer.Life (Basel). 2021;11:664. [DOI] [PubMed] [PMC]
Hvichia GE, Parveen Z, Wagner C, Janning M, Quidde J, Stein A, et al. A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells.Int J Cancer. 2016;138:2894–904. [DOI] [PubMed] [PMC]
Philippron A, Depypere L, Oeyen S, De Laere B, Vandeputte C, Nafteux P, et al. Evaluation of a marker independent isolation method for circulating tumor cells in esophageal adenocarcinoma.PLoS One. 2021;16:e0251052. [DOI] [PubMed] [PMC]
Xu L, Mao X, Imrali A, Syed F, Mutsvangwa K, Berney D, et al. Optimization and Evaluation of a Novel Size Based Circulating Tumor Cell Isolation System.PLoS One. 2015;10:e0138032. [DOI] [PubMed] [PMC]
Kitz J, Goodale D, Postenka C, Lowes LE, Allan AL. EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis.Clin Exp Metastasis. 2021;38:97–108. [DOI] [PubMed] [PMC]
Lampignano R, Yang L, Neumann MHD, Franken A, Fehm T, Niederacher D, et al. A Novel Workflow to Enrich and Isolate Patient-Matched EpCAMhigh and EpCAMlow/negative CTCs Enables the Comparative Characterization of the PIK3CA Status in Metastatic Breast Cancer.Int J Mol Sci. 2017;18:1885. [DOI] [PubMed] [PMC]
Wang L, Balasubramanian P, Chen AP, Kummar S, Evrard YA, Kinders RJ. Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells.Semin Oncol. 2016;43:464–75. [DOI] [PubMed] [PMC]
Pantel K, Alix-Panabières C. Circulating tumour cells in cancer patients: challenges and perspectives.Trends Mol Med. 2010;16:398–406. [DOI] [PubMed]
Bidard FC, Proudhon C, Pierga JY. Circulating tumor cells in breast cancer.Mol Oncol. 2016;10:418–30. [DOI] [PubMed] [PMC]