CTCs properties and related markers associated with EMT program in lung cancer

CTCs properties Biomarkers Ref.
Epithelial EpCAM, E-cadherin, CK7, CK8, CK18, CK19 [20, 21]
Mesenchymal Vimentin, N-cadherin, [21, 22]
EMT EpCAMLow, E-cadherinLow, CKLow, VimentinHigh, N-cadherinHigh, Twist [21, 22]
Stem-like CD44, CD133, ALDH1 [17, 22, 23]

EpCAM: epithelial cell adhesion molecule; CK: cytokeratin; ALDH1: aldehyde dehydrogenase 1