Exploration of Targeted Anti-tumor Therapy

Table 1. Clinical trials assessing the combination of selinexor with immunotherapy

Cancers	Indication	Immunotherapy combination with selinexor	NCT number	Status*	Phase
Haematological cancers	Double hit & triple hit lymphoma	Rituximab + CHOP	NCT05974085	Recruiting	II
	RR B cell lymphoma	Rituximab + GDP or rituximab + DHAOx	NCT02741388	Completed	I
	RR B cell lymphoma	Rituximab + ICE	NCT02471911	Completed	I
	EBV+ DLBCL	Rituximab + CHOP	NCT05577364	Recruiting	I/II
	RR DLBCL & indolent NHL	Rituximab + lenalidomide	NCT05265975	Recruiting	I/II
	RR B-NHL	CD19-CAR-T	NCT05322330	Unknown	II
	RRDLBCL	Rituximab + GDP	NCT04442022	Recruiting	II/III
	GCB-DLBCL	Rituximab + CHOP	NCT05422066	Recruiting	II
	R/RCLL NHL	Ibrutinib	NCT02303392	Unknown	I
	RR multiple myeloma (MM)	Daratumumab, pomalidomide or carfilzomib + dexamethasone	NCT04661137	Recruiting	II
	Newly diagnosed (ND) MM	Lenalidomide + bortezomib + dexamethasone	NCT05422027	Recruiting	I/II
	RR MM	Lenalidomide, thalidomide, or pomalidomide + dexamethasone	NCT04941937	Recruiting	II
	RR MM	Pomalidomide + dexamethasone	NCT05028348	Recruiting	III
	RR MM	Mezigdomide + dexamethasone	NCT02343042	Recruiting	I/II
	RR MM	Daratumumab + bortezomib + dexamethasone	NCT03589222	Unknown	II
		Daratumumab + carfilzomib + dexamethosone	NCT04756401	Active, not recruiting	II
		Lenalidomide	NCT04519476	Recruiting	I
	RR MM	Daratumumab, pomalidomide or carfilzomib + dexamethasone	NCT04925193	Active, not recruiting	II
	ND MM	Lenalidomide or bortezomib + dexamethasone	NCT04717700	Active, not recruiting	II
	High risk, ND MM	Daratumumab + bortezomib + dexamethasone	NCT06169215	Recruiting	II
	ND MM with extramedullary disease	Lenalidomide + bortezomib + dexamethasone	NCT05900882	Recruiting	II
	RR extramedullary MM	BCMA-CAR-T	NCT05201118	Unknown	I
	MM & myeloma-associated amyloidosis	Lenalidomide + dexamethasone	NCT05820763	Withdrawn	II
	ND MM	Daratumumab + lenalidomide + dexamethasone	NCT04782687	Active, not recruiting	II
Solid cancers	Advanced solid malignancy (not including brain tumors)	Ipilimumab Nivolumab Pembrolizumab Additional chemotherapy arms	NCT02419495	Terminated	I
	NSCLC or CRC	Pembrolizumab FOLFIRI Docetaxel	NCT04256707	Recruiting	I/II
	ND HCC	Bevacizumab + atezolizumab	NCT05093608	Terminated	I
	Advanced/Metastatic solid malignancy	Nivolumab + ipilimumab	NCT04850755	Unknown	I
	Advanced/Metastatic urothelial carcinoma	Pembrolizumab	NCT04856189	Recruiting	I/II
	Alveolar soft part sarcoma	Atezolizumab	NCT05333458	Recruiting	II
	Recurrent advanced melanoma	Pembrolizumab	NCT04768881	Terminated	II

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CAR: chimeric antigen receptor; DLBCL: diffuse large B cell lymphoma; RR: relapsed and refractory; BCMA: B cell maturation antigen; GCB: germinal center B-cell; NHL: non-Hodgkin lymphoma. *Trial status provided is according to information on clinicaltrials.gov as of (Date—01/23/2025); respective trial sponsor should be contacted for further clarification/information

Declarations

Author contributions

JGF: Conceptualization, Writing—original draft, Writing—review & editing. LGB: Writing—review & editing. TK: Writing—review & editing. CJW: Writing—review & editing. SIK: Writing—review & editing. MDB: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

TK and CJW are employees and stockholders of Karyopharm Therapeutics. All the other authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by Karyopharm Therapeutics and the John Goldman Fellowship Follow-up Award from Leukaemia UK (to MDB). Karyopharm Therapeutics reviewed the manuscript for scientific accuracy prior to submission but had no role in study design, data collection, analysis, interpretation, or writing of the manuscript; the other provider of funds had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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